4 rezultatet
General objective:
1. To evaluate the safety of EV71 vaccine in adults and in children age 6-71 months
2. To evaluate the immunogenicity of the vaccine in children by assessing the neutralization antibody levels before immunization; then 7, 15, 30 days after the first inoculation; and also 7, 15, 30
meningitis is a notifiable disease in many countries, the exact incidence rate is unknown. In 2013 meningitis resulted in 303,000 deaths - down from 464,000 deaths in 1990. In 2010 it was estimated that meningitis resulted in 420,000 deaths, excluding cryptococcal meningitis.
Bacterial meningitis
The study design is a prospective, placebo-controlled, randomized controlled trial using a convenience sample of 96 pediatric patients presenting for care in the emergency department who require an oropharyngeal examination as part of their evaluation. Examinations will be performed utilizing either
Background:
Hand foot and mouth disease outbreaks associated with enterovirus 71 (EV71) were unusual in their neurological manifestations. Since 1997, Taiwan, Malaysia and Vietnam have experienced large outbreaks of EV71-HFMD.
Neurological manifestations include meningitis, brainstem encephalitis,