Daidzin 80 mg, single dose, oral administration (4 capsules of Super-Absorbable Soy Isoflavones®).
Alcohol 0.5 g/kg (vodka diluted in lemon-flavoured water), single dose, oral administration. Solution of 150 ml.

Alcohol 0.5 g/kg (vodka diluted in lemon-flavoured water), single dose, oral administration. Solution of 150 ml.

Healthy

Super-Absorbable Soy Isoflavones, LifeExtension, USA. Single oral dose of 4 capsules (containing 80 mg of daidzin-daidzein).

Daidzin

Alcohol

Parc de Salut Mar.

Interaction Between a Natural Aldehyde Dehydrogenase 2 (ALDH2) Inhibitor and Alcohol

Human Pharmacology Study to Evaluate the Interaction Between a Natural Inhibitor of Aldehyde Dehydrogenase 2 (ALDH2) and Alcohol in Healthy Volunteers. Pilot Clinical Trial

Calculation of AUC for blood alcohol concentrations

Vital signs (heart rate, blood pressure, respiration rate, oral and facial temperature) and adverse effects measured by visual analogue scales (nausea, vomiting, vertigo, dizziness, headache, breathing difficulty, facial flushing)

Drunkenness and euphoria will be measured by a visual analogue scale (VAS).

Calculation of AUC of plasmatic concentrations of daidzein, genistein and equol

Collection of adverse events spontaneously reported by the participants and/or observed by the investigators.

Subjective effects will be measured with the Addiction Research Center Inventory (ARCI)

Calculation of elimination half-life from blood ethanol concentrations

Calculation of elimination half-life of plasmatic concentrations of daidzein, genistein and equol

Urine will be collected in the following periods:0-2h,2-8h,8-14h,14-24 h after administration. Concentrations of daidzein, genistein and equol will be measured

Parc de Salut Mar

Ministerio de Sanidad, Servicios Sociales e Igualdad

4 oz Haelan orally twice daily for 8 weeks

Fermented Soy Supplement

Sex: Female, Male

Region of Enrollment

Change in severity of poor appetite measured using a visual analog scale (VAS) of 0 to 100 mm (0 mm = best, 100 mm = worst) at week 4 +/- 5 days.

isoflavone/nausea

Interaction Between a Natural Aldehyde Dehydrogenase 2 (ALDH2) Inhibitor and Alcohol

Haelan and Nutrition in Cancer Patients

Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache

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