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nagilactone/podocarpus
Lidhja ruhet në kujtesën e fragmenteve
Faqja 1 nga 21 rezultatet
A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice.
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Identifikohuni Regjistrohu
Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that nagilactone B (NLB), a small molecule extracted from the root bark of Podocarpus nagi (Podocarpaceae), suppresses atherosclerosis in an atherosclerotic mouse
Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway.
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Identifikohuni Regjistrohu
Pulmonary fibrosis is a prototypic chronic progressive lung disease with high morbidity and mortality worldwide. Novel effective therapeutic agents are urgently needed owing to the limited treatment options in clinic. Herein, nagilactone D (NLD), a natural norditerpenoid obtained from Podocarpus
Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids.
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Identifikohuni Regjistrohu
Antifungal activity of three nagilactones isolated from the root bark of Podocarpus nagi (Podocarpaceae), alone and in combination with a variety of phenylpropanoids, was investigated against three fungi, Candida albicans, Saccharomyces cerevisiae, and Pityrosporum ovale. Nagilactone E [2], the most
Nagilactone E suppresses TGF-β1-induced epithelial-mesenchymal transition, migration and invasion in non-small cell lung cancer cells.
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Identifikohuni Regjistrohu
Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells.
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Identifikohuni Regjistrohu
Non-small cell lung cancer (NSCLC) is one of the most common forms and leading causes of cancer-related mortality worldwide, and discovery of new effective drugs still remains imperative to improve the survival rate. Nagilactone E (NLE) is a natural product isolated from Podocarpus nagi seeds, which
Antiproliferative Constituents of the Roots of Ethiopian Podocarpus falcatus and Structure Revision of 2α-Hydroxynagilactone F and Nagilactone I.
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Identifikohuni Regjistrohu
Bioassay-guided fractionation using the human colorectal adenocarcinoma (HT-29) cell line of the methanol extract of dried roots of Podocarpus falcatus led to the isolation of two new type C nagilactones, 16-hydroxynagilactone F (1) and 2β,16-dihydroxynagilactone F (2), and the new totarane-type
Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells
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Identifikohuni Regjistrohu
Nagilactone E (NLE), a natural product with anticancer activities, is isolated from Podocarpus nagi. In this study, we reported that NLE increased programmed death ligand 1 (PD-L1) expressions at both protein and mRNA levels in human lung cancer cells, and enhanced its localization on the cell
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity.
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Identifikohuni Regjistrohu
Norditerpenoids and dinorditerpenoids represent diterpenoids widely distributed in the genus Podocarpus with notable chemical structures and biological activities. We previously reported that nagilactone E (NLE), a dinorditerpenoid isolated from Podocarpus nagi, possessed anticancer effects against
Effect of nagilactone E on cell morphology and glucan biosynthesis in budding yeast Saccharomyces cerevisiae.
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Nagilactones are norditerpene dilactones isolated from the root bark of Podocarpus nagi. Although nagilactone E has been reported to show antifungal activities, its activity is weaker than that of antifungals on the market. Nagilactone E enhances the antifungal activity of phenylpropanoids such as
An antiproliferative norditerpene dilactone, Nagilactone C, from Podocarpus neriifolius.
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Identifikohuni Regjistrohu
An ethanolic extract of Podocarpus neriifolius D. Don (Podocarpaceae) showed antiproliferative activity against two major tumor cell lines, viz. human HT-1080 fibrosarcoma and murine color 26-L5 carcinoma. Bioassay guided fractionation showed the highest antiproliferative activity in
Anticancer Activities and Mechanism of Action of Nagilactones, a Group of Terpenoid Lactones Isolated from Podocarpus Species
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Identifikohuni Regjistrohu
Nagilactones are tetracyclic natural products isolated from various Podocarpus species. These lactone-based compounds display a range of pharmacological effects, including antifungal, anti-atherosclerosis, anti-inflammatory and anticancer activities reviewed here. The most active derivatives, such
Insect-control chemicals from plants. Nagilactone C, a toxic substance from the leaves of Podocarpus nivalis and P. hallii.
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Diterpenes, ionol-derived, and flavone glycosides from Podocarpus elongatus.
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Eight compounds, nagilactone C 7-O-α-L-arabinopyranosyl-(1→4)-β-D-xylopyranoside, nagilactone C 7-O-β-D-glucopyranosyl-(1→4)-β-D-xylopyranoside, nagilactone C 7-O-β-D-xylopyranoside, nagilactone A 7-O-α-L-arabinopyranosyl-(1→4)-β-D-xylopyranoside, 2β,15S,16,17,19-pentahydroxy-isopimar-8(14)-ene
Three diterpene dilactone glycosides from Podocarpus nagi.
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Identifikohuni Regjistrohu
Three water-soluble constituents, nagilactosides C-E, were isolated from Podocarpus nagi. Their structures were determined by chemical and spectroscopic methods, respectively. Nagilactoside C was identified as 1-deoxy-nagilactone A-2 alpha-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranoside,
Inhibition of lipid peroxidation by diterpenoid from Podocarpus nagi.
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Identifikohuni Regjistrohu
A diterpenoid, totarol (1), from Podocarpus nagi was evaluated as an antioxidant. This diterpenoid inhibited autoxidation of linoleic acid. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited. Nagilactone E (2), a norditerpene lactone
Baza e të dhënave më e plotë e bimëve medicinale e mbështetur nga shkenca
- Punon në 55 gjuhë
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- Organizoni interesat tuaja dhe qëndroni në azhurnim me kërkimet e lajmeve, provat klinike dhe patentat
Shkruani një simptomë ose një sëmundje dhe lexoni në lidhje me barërat që mund të ndihmojnë, shtypni një barishte dhe shikoni sëmundjet dhe simptomat që përdoren kundër.
* I gjithë informacioni bazohet në kërkimin shkencor të botuar
