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osteochondrodysplasias/obesity

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Body mass index (BMI): the case for condition-specific cut-offs for overweight and obesity in skeletal dysplasias.

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Case report: prenatal diagnosis of diastrophic dysplasia by ultrasound at 21 weeks of gestation in a mother with massive obesity.

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Routine prenatal ultrasound of a massively obese mother at 21 weeks of gestation revealed short-limb dwarfism in the fetus. The proportionate shortening of tubular bones of about 50 per cent of the normal length, the absence of thoracic dysplasia, and a normal head circumference narrowed the

Blood pressure in adults with short stature skeletal dysplasias.

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Hypertension, compounded by obesity, contributes to cardiovascular disease and mortality. Data describing hypertension prevalence in adults with short stature skeletal dysplasias are lacking, perhaps due to poor fit of typical adult blood pressure cuffs on rhizomelic or contracted upper extremities.

Anesthesia for bariatric surgery in an achondroplastic dwarf with morbid obesity.

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OBJECTIVE Achondroplasia is the most common form among the different types of osteochondrodysplasia that cause dwarfism. Dwarves develop obesity quite frequently and surgical treatment has shown greater efficacy, both for effective weight loss and long term maintenance. The objective of this report

Insulin-like growth factors in poultry.

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A large amount of research, primarily in mammals, has defined to a great extent the pleiotropic effects of the IGF system on growth, development, and intermediary metabolism. Similar elucidations in poultry were hindered to some extent by the absence of native peptides (IGF-I and IGF-II) until their

Impairment and activity limitation associated with epiphyseal dysplasia in children.

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OBJECTIVE To develop a profile of impairment and activity limitation among children with epiphyseal dysplasia (ED) and to identify the relationship between these 2 domains. METHODS Cross-sectional study. METHODS Acute, pediatric academic and health sciences center. METHODS Eleven subjects with

Perspectives: applications of a biomechanical model of the endochondral ossification mechanism.

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A biomechanical model of endochondral ossification (Frost and Jee, 1994. Anat. Rec., 240:435-446) can help to explain: (1) some differences in fracture patterns in children and adults, (2) increased fractures during the human adolescent growth spurt, (3) localization of stress fractures and

Majewski dwarfism type II: an atypical neuroradiological presentation with a novel variant in the PCNT gene.

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Microcephalic osteodysplastic primordial dwarfism syndrome II (MOPDII) is microcephalic primordial dwarfism and is a very rare form of disproportionate short stature. This disorder shares common features with other forms of microcephalic primordial dwarfism, including severe prenatal and postnatal

Achondroplasia

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Achondroplasia is a rare genetic disorder recognized as the most common primary skeletal dysplasia in humans. This form of dysplasia accounts for greater than 90% of cases of disproportionate short stature, also known as dwarfism. The term “achondroplasia” was first used in 1878 to distinguish it

Musculo-skeletal lesions in adult male broiler breeder fowls and their relationships with body weight and fertility at 60 weeks of age.

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1. Males from three broiler breeder experiments were examined to determine the incidence of musculo-skeletal lesions (destructive cartilage loss, dyschondroplasia and its sequelae, ruptured tendons and ligaments) in birds culled for low fertility and in males surviving to the end of the breeding

Bilateral epiphysiolysis of the femoral heads in two dogs.

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Two Shetland Sheepdogs that did not have a history of trauma were referred because of a gradual onset of lameness in the hind limbs. Bilateral slipped capital femoral epiphysis was diagnosed. Separation of the proximal femoral epiphysis that is not associated with trauma is recognized as a distinct

GeneReviews®

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Schmid metaphyseal chondrodysplasia (SMCD) is characterized by progressive short stature that develops by age two years. The clinical and radiographic features are usually not present at birth, but manifest in early childhood with short limbs, genu varum, and waddling gait. Facial

Autosomal Dominant TRPV4 Disorders

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Clinical characteristics: The autosomal dominant TRPV4 disorders (previously considered to be clinically distinct phenotypes before their molecular basis was discovered) are now grouped into neuromuscular disorders and skeletal

Achondroplasia

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Clinical characteristics: Achondroplasia is the most common cause of disproportionate short stature. Affected individuals have rhizomelic shortening of the limbs, macrocephaly, and characteristic facial features with frontal bossing and

INPPL1 gene mutations in opsismodysplasia.

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The INPPL1 (inositol polyphosphate phosphatase-like 1) gene encodes the inositol phosphatase, SHIP2 (for src homology 2 domain-containing inositol phosphatase 2). SHIP2 functions to dephosphorylate, and negatively regulate, the lipid second messenger phosphatidylinositol (3,4,5)P3. SHIP2 has been
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