osteoradionecrosis/hypoxia

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Avoiding Osteoradionecrosis - The Dental Surgeo's Nightmaren.

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Identifikohuni Regjistrohu

Osteoradionecrosis is a severe debilitating complication; it may occur from radiotherapy to the bones. It is a dental surgeon's nightmare as it may be long standing and difficult to manage. Osteoradionecrosis is characterised by hypoxia, hypocellularity and hypovascularity of the affected tissue.

Hyperbaric oxygen therapy and osteoradionecrosis.

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Identifikohuni Regjistrohu

Osteoradionecrosis of the mandible is a potentially devastating complication of head and neck radiation. Radiation causes progressive vascular occlusion with tissue hypoxia, tissue death, and failure of healing. Hyperbaric oxygen therapy is an accepted treatment for osteoradionecrosis. This article

Osteoradionecrosis of the skull after radiation therapy for invasive carcinoma.

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Identifikohuni Regjistrohu

Osteoradionecrosis (ORN) of the skull is a rare but fatal complication of radiation therapy for the treatment of head and neck malignancies. The pathogenesis of ORN follows the "3Hs Theory" proposed by Marx (J Oral Maxillofac Surg 1983;41:283-288) in which radiation induces tissue injury by causing

Osteoradionecrosis of Jaw in Head and Neck Cancer Patient Treated with Free Iliac Bone and Umbilical Fat Pad Graft.

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Identifikohuni Regjistrohu

Osteoradionecrosis is one of the most serious complications of patients receiving radiation therapy. It is characterized by hypovascularity, hypocellularity, and hypoxia-inducing necrosis of bone and soft tissue following delayed healing. In this case, a 72-year-old man was referred to the

Onset of mandible and tibia osteoradionecrosis: a comparative pilot study in the rat.

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Identifikohuni Regjistrohu

OBJECTIVE Osteoradionecrosis (ORN) is common in the jaws after radiotherapy. We hypothesized that the mandible is more susceptible to ORN than the tibia, based on site disparity in hypoxic, hypocellular, and hypovascular tissue breakdown. METHODS Twelve rats received 50 Gy irradiation to mandible or

Osteoradionecrosis of the skull base.

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Identifikohuni Regjistrohu

Radiation therapy (RT) is often necessary for the treatment of head and neck cancers. Osteoradionecrosis (ORN) is a rare, but potentially serious complication of RT. RT leads to the destruction of vasculature in radiated tissue causing hypoxia and tissue necrosis. ORN can occur in any bone, but

Mandible Osteoradionecrosis

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Identifikohuni Regjistrohu

Osteoradionecrosis (ORN) of the mandible is a severe iatrogenic disease of devitalized bone caused by radiation therapy of oral and oropharyngeal cancers. It is a state of injured bone tissue with inadequate healing or remodeling response of at least three to six months. The wound can result from

[Osteoradionecrosis. I. Etiology, pathogenesis, clinical aspects and risk factors].

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Identifikohuni Regjistrohu

In curative therapy of mouth-cavity and oropharyngeal carcinomas the osteoradionecrosis has to be accepted as a calculated risk with an incidence of 4-35%. It is the question of a radio-caused bone death that comes about by progressive and irreversible morphological alterations at bones and at

Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment.

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Identifikohuni Regjistrohu

During the past 80 years a number of theories about the pathogenesis of osteoradionecrosis (ORN) have been proposed, with consequent implications for its treatment. Until recently tissue hypoxia and its consequences were accepted as the primary cause, and this led to the use of hyperbaric oxygen

Osteoradionecrosis of the jaws--a current overview--part 1: Physiopathology and risk and predisposing factors.

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Identifikohuni Regjistrohu

OBJECTIVE The aim of this paper is to explore the current theories about definition, classification, incidence and physiopathology of osteoradionecrosis (ORN) of the jaws. Moreover, it is discussed the predisposing and risk factors for the development of osteoradionecrosis based on the literature

Treatment of mandibular osteoradionecrosis by periosteal free flaps.

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Identifikohuni Regjistrohu

Mandibular osteoradionecrosis (ORN) is one of the most serious complications of radiotherapy of the head and neck, and is characterised by hypoxia, hypovascularisation, and hypocellularity. Periosteal free flaps have intrinsic osteogenic, and extrinsic neoangiogenic, properties that are related to

Hyperbaric oxygen therapy in the management of carbon monoxide poisoning, osteoradionecrosis, burns, skin grafts, and crush injury.

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Identifikohuni Regjistrohu

OBJECTIVE To systematically assess the evidence for effectiveness of hyperbaric oxygen therapy in the treatment of conditions of significance in the West Midlands region and to determine whether there is a case for establishing a hyperbaric oxygen unit in the region. METHODS Systematic review of the

Challenges threaten, opportunity awaits hyperbaric medicine and the head and neck cancer patient.

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Identifikohuni Regjistrohu

Over the past four decades, hyperbaric oxygen (HBO2) therapy has played a prominent role in both the prevention and treatment of mandibular osteoradionecrosis (ORN). It has done so on the strength of laboratory observations and clinical reports, yet only limited efficacy data. This dual role has

Hyperbaric oxygen inhibits growth but not differentiation of normal and irradiated osteoblasts.

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Identifikohuni Regjistrohu

Hyperbaric oxygen (HBO) therapy is used in the treatment of osteoradionecrosis. Although HBO is thought to improve radiation-induced hypocellularity and bone tissue hypoxia, the precise effects of HBO on bone cells such as osteoblasts have not been described. In this study, our goal was to assess

Hyperbaric oxygen for treating wounds: a systematic review of the literature.

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Identifikohuni Regjistrohu

OBJECTIVE To determine whether hyperbaric oxygen (HBO) therapy is an effective adjunct treatment for hypoxic wounds. METHODS We identified studies from technology assessment reports on HBO and a MEDLINE search from mid-1998 to August 2001. We accepted randomized controlled trials (RCTs), cohorts,

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