15 rezultatet
The purposes of this study were (1) to investigate the chronology of events in cellular and biochemical changes thought to be important in the development of silicosis, (2) to relate these to changes in lung function and radiograph, and (3) to evaluate the relation of quartz exposure and retention
A 60-year-old stonemason, suffering for many years from joint pains and exertional dyspnoea, developed a high fever with weight loss. Physical examination revealed reddening of light-exposed skin areas, fine rales and overly warm and reddened hand and knee joints. Abnormal laboratory findings were
To clarify the indications and usefulness of Percutaneous endoscopic gastrostomy (PEG) in patients with Silicosis and some co-morbidities, we analyzed eight cases of silicosis, who suffered from dysphagia and had received a PEG for tube feeding during the period from 1998 to 2002. The
Possible determination of silicotuberculosis activity with various clinico-laboratory, roentgenological, biochemical and immunological procedures was analyzed by the materials on observation of patients with silicotuberculosis. The authors considered 117 observations relating to 88 male and 29
Results of an experimental study of the effect of quartz [DQ 12a1 administered intratracheally to Wistar line rats on the status of their immunological reactivity. The results obtained showed that a significant inhibition of antibody formation to human albumin took place in animals with experimental
Signs of kidney dysfunction detectable in urinary protein excretion were searched for in a group of 86 silica-exposed workers who were compared to 86 control subjects matched for age, smoking status and body mass index. No worker had any clinical, spirometric or radiographic sign of silicosis, and
In 84 patients with silicosis of various stages, a semi-quantitative topographical measurement of perfusion of the lung was performed with radionuclide albumin particles. At the same time, the scintigram of the lungs and x-ray films of the thorax were compared with each other. With increasing degree
Some results are brought concerning particular unspecific immunity indicators of experimental silicosis of Wistar rats induced by intratracheal quartz application (30 mg/kg "DQ12"). A decrease of antihuman antibody albumin production and an inhibition of blood neutrophil phagocytic response
Objective: To assess the incidence of silicosis among excavation workers in Suzhou city. Methods: In 2011-2016, we investigated the incidence of silicosis among 3190 excavation workers who participated in the mining operations from 1971 to 1974 in Suzhou city. To compare the general
Male Sprague-Dawley rats were subjected to a single, intratracheal instillation of 30 mg Min-U-Sil silica in sterile saline and were sacrificed 3, 7, or 14 days following instillation. Control animals were instilled with sterile saline only. Silica instillation produced an inflammatory reaction
An understanding of the mechanisms underlying diseases is critical for their prevention. Excessive exposure to crystalline silica is a risk factor for silicosis, a potentially fatal pulmonary disease. Male Fischer 344 rats were exposed by inhalation to crystalline silica (15 mg/m3, six hours/day,
Exposure to crystalline silica results in serious adverse health effects, most notably, silicosis. An understanding of the mechanism(s) underlying silica-induced pulmonary toxicity is critical for the intervention and/or prevention of its adverse health effects. Rats were exposed by inhalation to
OBJECTIVE
The aim of this study was to determine whether silicosis is associated with renal alterations detectable in urinary or blood-borne indicators of nephrotoxicity.
METHODS
The study used a cross-sectional design. The subjects comprised 116 male workers who had been exposed to silica for at
It has previously been shown that granite workers with heavy exposure to silica had glomerular and proximal tubular dysfunction evidenced by increased urinary excretions of albumin, alpha-1-microglobulin (AMG), and beta-N-acetyl-glucosaminidase (NAG). The investigation was replicated in another
Alkaline phosphatase (ALP) in lung lavage fluids is a marker of tissue damage and type II cell proliferation. Type II pneumocytes are extensively involved in fibrosis. The aim of our study was to verify whether local ALP activity can be held as a marker of fibrosis in chronic interstitial lung