silydianin/inflammation

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An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species.

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Identifikohuni Regjistrohu

The inhibitory effect of silydianin, an active constituent of Silybium marianum, on the in vitro production and release of oxidative products has been examined. Polymorphonuclear neutrophils (PMNs) play a primary role in the initiation and propagation of inflammatory responses. Their apoptosis is a

Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase.

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Identifikohuni Regjistrohu

Silymarin, a mixture of flavonolignans, comprised mainly of three isomers, silybin, silydianin and silychristin isolated from the fruits of Silybum marianum, is currently in therapeutic use as a hepatoprotective agent. Silymarin on evaluation exhibited significant antiinflammatory and antiarthritic

Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-Inflammatory Potential in Callus Cultures of Silybum marianum (L.) Gaertn.

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Identifikohuni Regjistrohu

Silybum marianum (L.) Gaertn. is a well-known medicinal herb, primarily used in liver protection. Light strongly affects several physiological processes along with secondary metabolites biosynthesis in plants. Herein, S. marianum was exploited for in vitro potential under different

Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and Leukocytes.

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Identifikohuni Regjistrohu

Interleukin-1 beta (IL-1β)-the most potent pro-inflammatory is responsible for a broad spectrum of immune and inflammatory responses, it induces T-cell and B-cell activation and consequently the synthesis of other pro-inflammatory cytokines (such as IFN-γ and TNF). IL-1β induces the formation of

Flavonolignans inhibit the arachidonic acid pathway in blood platelets.

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Identifikohuni Regjistrohu

BACKGROUND Arachidonic acid metabolism by cyclooxygenase (COX) is a major pathway for blood platelets' activation, which is associated with pro-thrombotic platelet activity and the production of pro-inflammatory mediators. Inhibition of COX activity is one of the major means of anti-platelet

Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models.

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Identifikohuni Regjistrohu

Flavonolignans are the main components of silymarin, which represents 1.5-3% of the dry fruit weight of Milk thistle (Silybum marianum L. Gaernt.). In ancient Greece and Romania, physicians and herbalists used the Silybum marianum to treat a range of liver diseases. Besides their hepatoprotective

Immunomodulatory effects of two silymarin isomers in a Balb/c mouse model of allergic asthma.

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Identifikohuni Regjistrohu

Allergic asthma is a complex chronic disease of the respiratory system presenting with cough, dyspnea, wheezing and airway obstruction. More than 300 million people of all age spectrums suffer from asthma worldwide. Immunological and inflammatory processes are main contributors to

Stability of the constituents of Calendula, milk-thistle and passionflower tinctures by LC-DAD and LC-MS.

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Identifikohuni Regjistrohu

As a part of our investigations on the stability of tinctures, we evaluated 40 and 60% v/v tinctures of Calendula flower, Milk-thistle fruit and Passionflower. These preparations are widely employed in phytotherapy, thus Calendula is used externally for anti-inflammatory properties, Milk-thistle and

Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.

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Identifikohuni Regjistrohu

Silymarin, a flavonolignan from 'milk thistle' (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany alone. In this review we discuss about its safety, efficacy and future uses in liver diseases. The use of silymarin may

Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: a review.

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Identifikohuni Regjistrohu

Biological and chemical agents cause dangerous effects on human health via different exposing ways. Recently, herbal medicine is considered as a biological and safe treatment for toxicities. Silybum marianum (milk thistle), belongs to the Asteraceae family, possesses different effects such as

A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma.

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Identifikohuni Regjistrohu

Silymarin, an extract of crushed achenes of the milk thistle plant Silybum marianum is a multi-constituent mixture, 70-80% of which consists of a complex assortment containing the flavonolignans silybin A and B, isosilybin A and B, silydianin, and silychristin, and the flavonoid taxifolin. To date,

Anticancer potential of silymarin: from bench to bed side.

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Identifikohuni Regjistrohu

Silymarin consists of a family of flavonoids (silybin, isosilybin, silychristin, silydianin and taxifoline) commonly found in the dried fruit of the milk thistle plant Silybum marianum. Although silymarin's role as an antioxidant and hepatoprotective agent is well known, its role as an anticancer

Synthesis of bio-mediated silver nanoparticles from Silybum marianum and their biological and clinical activities.

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Identifikohuni Regjistrohu

The purpose of current study was green synthesis of silver nanoparticles (AgNPs) from seeds and wild Silybum plants in comparison with their respective extracts followed by characterization and biological potency. The biologically synthesized AgNPs were subjected to characterization using techniques

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