group C for MRI, neuropsychological and ecological assessments

Multiple Sclerosis

Cognitive Rehabilitation

Individual rehabilitation procedures will be focused on attention, executive functions, IPS and working memory. The program will be tailored to each patient cognitive status depending on the impairments identified during the initial assessment while maintaining a systematic work on attention and executive functions. A total of 50 sessions lasting one hour at a rate of 3 sessions per week for a total period of 4 months will be proposed. Sessions will include varied exercises according to complexity and presentation modality, using computerized and "paper-and-pencil" tasks and metacognitive training. Work will be progressive, depending on the progresses achieved (increase complexity and intensity of the exercises according to success at the previous level of exercises).

specific cognitive rehabilitation

A total of 50 sessions lasting one hour at a rate of 3 sessions per week for a total period of 4 months will be proposed by group composed to 5 patients

non specific cognitive rehabilitation

no intervention

Service de Neurologie - Pôle des Neurosciences Cliniques, CHU de Bordeaux.

Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis

Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis and Assessment by Neuroimaging

University Hospital, Bordeaux

Merck Serono International SA

ARSEP foundation

Down's Syndrome

Dementia

Learning Disabilities

Memantine Hydrochloride

Northgate Hospital

Monyhull Hall Road

Memantine and Down's Syndrome

Efficacy and Safety of Memantine Hydrochloride, a Low Affinity Antagonist to N-Methyl-D-Aspartate (NMDA) Type Receptors, in the Prevention of Cognitive Decline and Disease Progression in Down's Syndrome

King's College London

Investigate biochemical, functional, and structural neuroimaging changes following non-invasive brain stimulation in patients with chronic widespread pain: fibromyalgia (FM). We will be using tDCS as intervention.

Fibromyalgia

tDCS is based on the application of a weak direct current to the scalp that flows between two relatively large electrodes-anode and cathode. We will be using this device to investigate fibromyalgia.

Transcranial Direct Current Stimulation (tDCS)

University of Michigan - Michigan Center for Oral Health Research

Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia

Determine the effects of tDCS on the excitatory neurotransmitter glutamate (Glu) within the insula (posterior and anterior) and thalamus in individuals with FM. Glu levels within the insula and thalamus will be reduced following tDCS, reflecting a down regulation of excitatory neurotransmission in these pain regions.

Investigate whether long-term therapy with tDCS normalizes gray matter thickness in target and cortical areas associated with pain perception and modulation in FM. Cortical thickness in FM patients, will return to comparable age- and sex-matched pain-free control participant levels following tDCS. These effects will be specifically detected in pain modulatory regions (e.g. dorsal lateral prefrontal cortex) of FM patients

white/tonik

Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis

Memantine and Down's Syndrome

Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia

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