Healthy

Diet Modification

Analysis of endothelial function, oxidative stress

Endothelial function and inflammation

Erasme Hospital

Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores.

Differential Analysis of Uric Acid Metabolism, Endothelial Function, Oxidative Stress and Cardiovascular Parameters in Vegans and Omnivores.

Endothelial function assessment will be performed through analyse of the perfusion of the microcirculation of the skin in the forearm will be assessed by means of a laser Doppler imager and iontophoresis of acetylcholine and sodium nipride. Heating-induced hyperemia will be assessed after iontophoresis of inhibitor of NO synthase and saline. Units are perfusion unit.
Iontophoresis is a non-invasive tool which permits to infuse molecules in the first micrometers of the skin. The used molecules are vasodilative, saline or NO synthase inhibitor.

Sera will be used for cell cultures. Theses cells will be lysed and used to analyse and compare the different proteomes / metabolomes according to the groups. We will be able to understand which protein groups are reduced or enhanced according to the diet.

Diet History Questionnaire third version provides estimation of one year consumption of proteins, carbohydrates, lipids, micronutrient and vitamines

Erasme University Hospital

Fonds National de la Recherche Scientifique

Fonds Erasme

Fonds pour la chirurgie cardiaque

70 subjects with biopsy-proven NAFLD; subjects will be challenged with a fructose infusion after a period for 12 hours fasting.

15 healthy controls for comparison with NALFD patients.The 15 subjects will be challenged with a fructose infusion after a period for 12 hours fasting.

Nonalcoholic Fatty Liver Disease (NAFLD)

Patients will be admitted to our Duke Clinical Research Unit (DCRU) at least 12 hours prior to morning intravenous fructose challenge. All patients will have a "standard" meal in order to control for dietary composition and calorie intake prior to intravenous fructose challenge. Patients will be NPO after midnight for morning IV fructose MR biomarker measures. Patients with suspected NAFLD will have a standard of care , liver biopsy followed by , and co-localization of liver biopsy with MR.

intravenous fructose challenge

Duke University Medical Center

Impact of Fructose on Metabolism, Energy Homeostasis and MR Biomarkers in NAFLD

Impact of Fructose on Metabolism, Energy Homeostasis and MR Biomarkers in Nonalcoholic Fatty Liver Disease (NAFLD)

Exploratory study to evaluate the acute (baseline and dynamic) changes in metabolism and in energy homeostatic in volunteers and patients with biopsy-proven NAFLD measures following IV challenge and dietary fructose restriction.

Exploratory study to evaluate the acute (baseline and dynamic) changes MR biomarkers in volunteers and patients with biopsy-proven NAFLD measures following IV challenge and dietary fructose restriction.

xanthine dehydrogenase/inflammation

Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores.

Impact of Fructose on Metabolism, Energy Homeostasis and MR Biomarkers in NAFLD

Mucomyst for Hepatitis C

Baza e të dhënave më e plotë e bimëve medicinale e mbështetur nga shkenca