Tissue Alterations in Aggressive and Chronic Periodontitis
Кључне речи
Апстрактан
Опис
Periodontal disease disrupts soft tissue metabolism in the gingiva through a decrease in the production of collagen, the quality, and quantity of the connective tissue. The etiology and pathogenesis of chronic periodontitis are mostly revealed however, there are many dark points in the etiopathogenesis of aggressive periodontitis. The existence of periodontal destruction at even one tooth in the mouth increases the risk of further periodontal destruction. However, the incidence of progression of the disease to the unaffected teeth was not demonstrated. Yet, the progression of the disease from diseased sites to healthy sites is likely to occur but no evidence is present comparing healthy and diseased sites of chronic and aggressive periodontitis. Present study aimed to evaluate the histological changes in both diseased and healthy sites in both localized aggressive periodontitis (LAgP) and chronic periodontitis (CP) patients by determining fibroblast and inflammatory cell counts in histologic slides and immunohistochemical staining of enzymes and hypoxia markers in order to better understand the dimensions of this demolition in periodontal disease.
Датуми
| Последња верификација: | 07/31/2018 |
| Фирст Субмиттед: | 08/06/2018 |
| Предвиђена пријава послата: | 08/06/2018 |
| Прво објављено: | 08/09/2018 |
| Послато последње ажурирање: | 08/08/2018 |
| Последње ажурирање објављено: | 08/12/2018 |
| Стварни датум почетка студије: | 01/31/2017 |
| Процењени датум примарног завршетка: | 01/31/2018 |
| Предвиђени датум завршетка студије: | 05/31/2018 |
Стање или болест
Фаза
Групе руку
| Арм | Интервенција / лечење |
|---|---|
| Healthy individuals Gingival biopsies of healthy individuals who had no systemic or oral disease or condition. | |
| Unaffected sites of CP Chronic periodontitis patients had teeth affected from destruction and some teeth were unaffected. Gingival biopsies of chronic periodontitis patients were taken from sites which were not affected by periodontal destruction. | |
| Affected sites of CP Chronic periodontitis patients had teeth affected from destruction and some teeth were unaffected. Gingival biopsies of chronic periodontitis patients were taken from sites which were affected by periodontal destruction. | |
| Unaffected sites of LAgP Like chronic periodontitis, aggressive periodontitis patients had also teeth affected by destruction and some teeth were unaffected. Gingival biopsies of aggressive periodontitis patients were taken from sites which were not affected by the periodontal destruction. | |
| Affected sites of LAgP Like chronic periodontitis, aggressive periodontitis patients had also teeth affected by destruction and some teeth were unaffected. Gingival biopsies of aggressive periodontitis patients were taken from sites which were affected by the periodontal destruction. |
Критеријуми
| Узраст подобан за студирање | 30 Years До 30 Years |
| Полови подобни за студирање | All |
| Метода узорковања | Probability Sample |
| Прихвата здраве волонтере | да |
| Критеријуми | Inclusion Criteria: Age range from 30 to 45, the existence of at least 20 functioning teeth, no history of smoking, systemical health, no antibiotic use within 6 months, no periodontal therapy within 6 months, no pregnancy or lactation, no drug use, in addition; For healthy individuals, the existence of oral health - For localized aggressive periodontitis, the existence of the disease at least for 5 years, the presence of both healthy and diseased sites in the same patient. - For chronic periodontitis, the existence of the disease at least for 5 years, the presence of both healthy and diseased sites in the same patient. Exclusion Criteria: - Patients younger than 30 older than 45 years old, the absence of occlusion, drug use, pregnancy/lactation, smoking, previous antibiotic use, previous periodontal therapy, the existence of any systemical disease. |
Исход
Примарне мере исхода
1. Fibroblast and total inflammatory cell counts [Biopsies were obtained a day after initial examinations, histological analysis were performed 2 weeks after.]
Секундарне мере исхода
1. Immunohistochemical staining [Biopsies were obtained a day after initial examinations, histological analysis were performed 2 weeks after]
