Amino Acid Therapy for Hot Flashes in Postmenopausal Women
Кључне речи
Апстрактан
Опис
Hot flashes affect approximately 75% of postmenopausal women. Although hormone replacement therapy (HRT) is highly effective in reducing hot flashes, long-term HRT is associated with increased rates of breast cancer and heart disease. Safe, effective, and well-tolerated hot flash therapies are needed. The amino acids L-methionine and L-isoleucine have produced reductions in hot flash frequency. However, long-term L-methionine therapy may increase cardiovascular risks. This study will evaluate the short-term effects of L-isoleucine therapy. Data from this study will be used to conduct long-term studies in the future.
Participants in this study will be randomly assigned to receive one of two different L-isoleucine doses for 2 weeks. Clinic visits will be made at baseline, Week 1, and Week 10. Participants will record the frequency and severity of their hot flashes in a diary.
Датуми
| Последња верификација: | 02/28/2013 |
| Фирст Субмиттед: | 04/26/2004 |
| Предвиђена пријава послата: | 04/26/2004 |
| Прво објављено: | 04/27/2004 |
| Послато последње ажурирање: | 03/20/2013 |
| Последње ажурирање објављено: | 03/21/2013 |
| Стварни датум почетка студије: | 09/30/2003 |
| Процењени датум примарног завршетка: | 09/30/2007 |
| Предвиђени датум завршетка студије: | 09/30/2007 |
Стање или болест
Интервенција / лечење
Drug: L-norleucine
Фаза
Критеријуми
| Полови подобни за студирање | Female |
| Прихвата здраве волонтере | да |
| Критеријуми | Inclusion Criteria: - Postmenopausal - Experience over 5 hot flashes per day Exclusion Criteria: - Hormone Replacement Therapy (HRT) in the past 2 months |
