Effects of Intraoperative GDFT on the Postoperative Brain Edema
Кључне речи
Апстрактан
Датуми
| Последња верификација: | 05/31/2020 |
| Фирст Субмиттед: | 10/23/2017 |
| Предвиђена пријава послата: | 10/23/2017 |
| Прво објављено: | 10/26/2017 |
| Послато последње ажурирање: | 06/07/2020 |
| Последње ажурирање објављено: | 06/10/2020 |
| Стварни датум почетка студије: | 12/19/2017 |
| Процењени датум примарног завршетка: | 09/30/2022 |
| Предвиђени датум завршетка студије: | 10/31/2022 |
Стање или болест
Интервенција / лечење
Other: SVV-based GDFT group
Other: non-SVV-based GDFT group
Фаза
Групе руку
| Арм | Интервенција / лечење |
|---|---|
| Experimental: SVV-based GDFT group The patients will receive fluid therapy under SVV-directed goal. | Other: SVV-based GDFT group Target SVV will be titrated with fluid bolus, and thus individual amount varied depending on the SVV value at that time. Maintenance of oxygenation, hemoglobin, blood glucose, core temperature and hemodynamics, such as minimal cardiac indices, mean arterial pressure and heart rate, will be applied according to the same standard for each patient. |
| Sham Comparator: non-SVV-based GDFT group The patients will receive fluid therapy without SVV-directed goal. | Other: non-SVV-based GDFT group Fluid therapy will be done without goal-directed SVV . Maintenance of oxygenation, hemoglobin, blood glucose, core temperature and hemodynamics, such as minimal cardiac indices, mean arterial pressure and heart rate, will be applied according to the same standard for each patient. |
Критеријуми
| Узраст подобан за студирање | 18 Years До 18 Years |
| Полови подобни за студирање | All |
| Прихвата здраве волонтере | да |
| Критеријуми | Inclusion Criteria: 1. Preoperative brain image indicating high-grade glioma (HGG), verified by postoperative histology of the World Health Organization (WHO) as grade III or IV tumors. 2. Age 18 -80 years. 3. Undergoing supratentorial brain tumour resection. 4. Signed informed consent. Exclusion Criteria: 1. Renal insufficiency or the creatinine clearance is < 30 mL/kg. 2. Heart disease, New York Heart Association Functional Classification (NYHA) class II or higher heart failure, or if their cardiac ejection fraction is < 20%. 3. Chronic obstructive pulmonary disease. 4. Extensive peripheral arterial occlusive disease. 5. Coagulopathy. 6. Surgery in the prone position. |
Исход
Примарне мере исхода
1. Quantitative analysis of brain edema [Postoperative-1 day]
