L-5-HTP-Related EMS

Само регистровани корисници могу преводити чланке

Пријави се / Пријави се

Веза се чува у привремену меморију

СтатусЗавршено

Спонзори

National Institute of Mental Health (NIMH)

КЛИНИЧКО ИСПИТИВАЊЕ: NCT00001918

BioSeek: nct00001918

Кључне речи

Апстрактан

In 1989 more than 1500 people who took the dietary supplement L-tryptophan for insomnia and depression developed eosinophilia myalgia syndrome (EMS)-a potentially fatal disease characterized by an excess of a type of white blood cell called eosinophils. Disease symptoms include fever, muscle aches and inflammation, and skin rashes. As many as 40 of the patients who became ill died. It is suspected that impurities in the supplements caused the disease. More recently, similar impurities have been detected in batches of a similar dietary supplement called L-5-hydroxytryptophan.

This study is designed to learn more about EMS that develops in patients taking L-5-hydroxytryptophan. The study is open to patients newly diagnosed with eosinophilia myalgia who have taken L-5-HTP. Patients in the study will have a physical examination and urine and blood tests. They may also have X rays, an electrocardiogram, magnetic resonance imaging (MRI), and a skin test for tuberculosis. They will have a psychiatric interview, take a memory test, and fill out questionnaires relating to sadness and depression.

Patients may also undergo special tests to study conduction of nerve impulses and muscle function.

Samples of patients' supplements will be taken for chemical analysis.

Опис

The L-tryptophan-related eosinophilia myalgia syndrome (EMS), characterized by eosinophilia, myalgias, myositis, scleroderma-like skin fibrosis and fasciitis, occurred in 1989 in over 1500 patients who had ingested L-tryptophan for sleep disturbances and depression. The identical clinical syndrome has also occurred in subjects ingesting L-5-hydroxytryptophan (L-5-HTP).

Recently, a letter to Nature Medicine reported the presence of an impurity in 6 out of 6 samples of L-5-HTP obtained randomly at health food stores. This impurity appears to be the same as the one identified in material ingested by a family (mother and 2 babies) who had developed an EMS-like syndrome after ingesting L-5-HTP.

Although there have been no definite new cases of L-5-HTP-related EMS, the FDA is currently investigating unconfirmed reports of possible new cases.

Датуми

Последња верификација:	05/31/1999
Фирст Субмиттед:	11/02/1999
Предвиђена пријава послата:	12/08/2002
Прво објављено:	12/09/2002
Послато последње ажурирање:	03/02/2008
Последње ажурирање објављено:	03/03/2008
Стварни датум почетка студије:	06/30/1999
Предвиђени датум завршетка студије:	07/31/2000

Стање или болест

Eosinophilia-Myalgia Syndrome

Фаза

Критеријуми

Полови подобни за студирање

All

Прихвата здраве волонтере

да

Критеријуми

Patients must be at least 18 years of age.

Patients newly diagnosed with eosinophilia and myalgia, and who ingested L-5-HTP.

Subjects will be defined as having 5-L-HTP related EMS according to the diagnostic criteria originally established by the CDC for diagnosis of L-tyrptophan-related EMS.

L-5-HTP-Related EMS

Кључне речи

триптофан

l tryptophan

туберкулоза

fibroza

запаљење

грозница

мијалгија

myositis

fasciitis

eosinophilia

Апстрактан

Опис

Датуми

Стање или болест

Фаза

Критеријуми

Најкомплетнија база лековитог биља подржана науком