Pilot Study on the Tolerability of Dietary Dried Plum
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СтатусЗавршено
Спонзори
University of California, San Francisco
КЛИНИЧКО ИСПИТИВАЊЕ: NCT01035372
BioSeek: nct01035372
Кључне речи
Апстрактан
Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.
Датуми
| Последња верификација: | 01/31/2020 |
| Фирст Субмиттед: | 12/15/2009 |
| Предвиђена пријава послата: | 12/15/2009 |
| Прво објављено: | 12/17/2009 |
| Послато последње ажурирање: | 02/25/2020 |
| Последње ажурирање објављено: | 03/01/2020 |
| Стварни датум почетка студије: | 11/30/2009 |
| Процењени датум примарног завршетка: | 08/31/2010 |
| Предвиђени датум завршетка студије: | 08/31/2010 |
Стање или болест
Healthy
Elderly
Интервенција / лечење
Dietary Supplement: dried plum
Фаза
-
Групе руку
| Арм | Интервенција / лечење |
|---|---|
| Experimental: dried plum subjects will have 25% by weight (~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder | Dietary Supplement: dried plum subjects will have 25% of their diet substituted by dried plum powder |
Критеријуми
| Узраст подобан за студирање | 50 Years До 50 Years |
| Полови подобни за студирање | All |
| Прихвата здраве волонтере | да |
| Критеријуми | Inclusion Criteria: - Age between 50 yrs and 75 yrs - Nonsmokers - Normal renal and hepatic function Exclusion Criteria: - Subjects who must follow a specific diet - Subjects on any daily medications that affect bone health - Subjects too heavy for the DEXA machine (weight limit 300 lbs) - Subjects whose BMD by DEXA indicates osteoporosis - Subjects unwilling to follow the diet specified - Pregnant women - Subjects who are unable to understand the consent form. |
Исход
Примарне мере исхода
1. urinary calcium excretion [one month]
Секундарне мере исхода
1. ability to tolerate the diet [one month]
