Sleep Apnea in Asthmatic Children and Teenagers
Кључне речи
Апстрактан
Опис
Obstructive sleep apnea (OSA) and asthma are both inflammatory airway diseases. A systematic review regarding sleep-disordered breathing (SDB) in asthmatic children analyzed 17 studies but only two of them had objective OSA measurement. In total, 45,115 children were included, 53% boys, mean age 8.6 ± 2.5 years. SDB was present in 23.8% of asthmatic children and in 16.7% of non-asthmatic (p < 0.001, OR 1.9, 95%CI 1.7-2.2).
An American study found that OSA in asthmatic children increases hospital length of stay (OR 2.3; 95% CI = 1.8 - 2.9). Brazilian database of the year 2015 showed that, among children 5-19 years, asthma was the 5th cause of hospitalization: a total of 2.4% of the hospitalization in this age group, after birth and its complication (31%), limb fractures (5.7%), pneumonia (3.8%), and appendicitis (3.2%).
The relationship among asthma severity (mild, moderate, and severe) and OSA has been described previously, but not in every study. Poor asthma control has also been linked to a higher OSA risk in adults and children.
OSA and asthma share many risk factors: rhinitis, increased collapsibility of the upper airway, local and systemic inflammation, gastroesophageal reflux, and obesity.
A higher risk of SDB in asthmatic girls has recently been described (OR 2.55 for girls and 0.70 for boys). Among non-asthmatic children OSA is usually equal among boys and girls until adolescence. A possible explanation is asthma severity in children: younger boys are more severe but after puberty, girls are.
Since OSA and asthma are linked diseases and that little is known about them in the pediatric field, specially differences related to sex, the investigators hypothesize that: 1) asthmatic girls have a higher OSA risk; 2) OSA will be higher in asthmatic children compared to the pediatric literature; 3) asthma severity, asthma control, and rhinitis will be related to a higher OSA risk. The investigators also aim to analyze factors associated with a higher risk of hospitalizations and asthma attacks.
Датуми
| Последња верификација: | 01/31/2019 |
| Фирст Субмиттед: | 01/19/2017 |
| Предвиђена пријава послата: | 01/24/2017 |
| Прво објављено: | 01/26/2017 |
| Послато последње ажурирање: | 02/13/2019 |
| Последње ажурирање објављено: | 02/14/2019 |
| Стварни датум почетка студије: | 11/30/2016 |
| Процењени датум примарног завршетка: | 08/31/2018 |
| Предвиђени датум завршетка студије: | 08/31/2018 |
Стање или болест
Интервенција / лечење
Other: Asthma
Other: Asthma
Other: Asthma
Фаза
Групе руку
| Арм | Интервенција / лечење |
|---|---|
| Other: Asthma Children and teenagers with persistent asthma will perform questionnaires, lung function test, and home sleep study | Other: Asthma Children and parents are going to inform data regarding socioeconomical status, asthma and rhinitis diagnosis, asthma and rhinitis control, medications, sleep complaints, and sleep habits |
Критеријуми
| Узраст подобан за студирање | 7 Years До 7 Years |
| Полови подобни за студирање | All |
| Прихвата здраве волонтере | да |
| Критеријуми | Inclusion Criteria: - Persistent asthma Exclusion Criteria: - Craniofacial malformation - Thoracic malformation - Genetic syndromes - Bronchopulmonary dysplasia - Bronchiolitis obliterans - Neuromuscular diseases - Sickle cell anemia - Cystic fibrosis |
Исход
Примарне мере исхода
1. Sleep Apnea Syndrome [1 night]
Секундарне мере исхода
1. Asthma Control [4 weeks]
2. ER visits [1 year]
3. Lung function [1 day]
