Stevia Extract and Glucose Homeostasis
Кључне речи
Апстрактан
Опис
The study is a three-arm crossover trial involving participants attending the Lab on 3 different occasions (separated by 3-5 day washout period), where they will be administered water, sugar solution (65g), water and stevia extract (5g) solution. The solution will be followed by a consumption of a fixed meal (after 30 minutes). Breakfast will be standardised. Capillary blood glucose will be collected every 30 min until 2 hours post meal. Venous blood samples will be collected before the intake of the solution and at 2 hours after meal intake.
Датуми
| Последња верификација: | 03/31/2020 |
| Фирст Субмиттед: | 04/01/2020 |
| Предвиђена пријава послата: | 04/01/2020 |
| Прво објављено: | 04/05/2020 |
| Послато последње ажурирање: | 04/06/2020 |
| Последње ажурирање објављено: | 04/08/2020 |
| Стварни датум почетка студије: | 03/02/2020 |
| Процењени датум примарног завршетка: | 02/14/2021 |
| Предвиђени датум завршетка студије: | 02/14/2021 |
Стање или болест
Интервенција / лечење
Other: sugar replacements
Фаза
Групе руку
| Арм | Интервенција / лечење |
|---|---|
| No Intervention: Water 250 ml of water mixed with 1g of citric acid. | |
| Active Comparator: Sugar 65g of sugar dissolved in 250ml of water | |
| Experimental: Stevia 5g of stevia dissolved in 250ml of water |
Критеријуми
| Узраст подобан за студирање | 18 Years До 18 Years |
| Полови подобни за студирање | All |
| Прихвата здраве волонтере | да |
| Критеријуми | Inclusion Criteria: - Age 18-65 years - BMI 27-40 Kg/m2 - Males and females Exclusion Criteria: - Athletes - Pregnant or breastfeeding women - Patients with chronic disease (diabetes, CVD etc…). |
Исход
Примарне мере исхода
1. Postprandial glucose levels [Capillary blood glucose will be measured two hours after the administration of a fixed meal.]
Секундарне мере исхода
1. Postprandial insulin levels [Postprandial insulin levels will be measured two hours of the administration of a fixed meal]
2. Area under the curve (AUC) for glucose [Capillary blood glucose levels will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch]
3. Subjective feelings of satiety [VAS will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch.]
