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bladder/hypoxia

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Страна 1 од 502 резултати

Bladder outlet obstruction accelerates bladder carcinogenesis.

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OBJECTIVE To examine the correlation between partial bladder outlet obstruction (PBOO) and bladder carcinogenesis. METHODS Female Wistar rats (6 weeks old) were divided into three groups of 10 each: group 1 was exposed to n-butyl-n-butanol nitrosamine (BBN, a carcinogen) in drinking water for 8

Ischemia, Hypoxia and Oxidative Stress in Bladder Outlet Obstruction and Bladder Overdistention Injury.

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Ischemia and the accompanied hypoxia significantly impair the function of the urinary bladder, which is further damaged by ischemia/reperfusion (I/R) injury following the re-establishment of the blood supply. Current evidences have confirmed that blood flow of the bladder is decreased by bladder

Hypoxia inhibits human bladder smooth muscle cell proliferation: a potential mechanism of bladder dysfunction.

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OBJECTIVE Recent animal studies have suggested that bladder outflow obstruction causes bladder wall hypoxia during both the filling and the voiding phases of the micturition cycle. We have previously demonstrated that mechanical deformation of human detrusor leads to smooth muscle (SM) cell

Hypoxia inhibits human bladder smooth muscle cell proliferation: a potential mechanism of bladder dysfunction.

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Metallothionein overexpression of bladder biopsies associated with tissue hypoxia in patients with interstitial cystitis/painful bladder syndrome.

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OBJECTIVE To study the relationship between hypoxia and metallothionein expression in bladder biopsies of interstitial cystitis/painful bladder syndrome patients. METHODS The study group consisted of 41 patients with interstitial cystitis/painful bladder syndrome, and the control group consisted of

Inhibition of HIF Reduces Bladder Hypertrophy and Improves Bladder Function in Murine Model of Partial Bladder Outlet Obstruction.

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OBJECTIVE Posterior urethral valves are the most common cause of partial bladder outlet obstruction in the pediatric population. However, to our knowledge the etiology and the detailed mechanisms underlying pathological changes in the bladder following partial bladder outlet obstruction remain to be

Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders.

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The ability to repair damaged urinary bladders through the application of bone marrow-derived cells is in the earliest stages of development. We investigated the application of bone marrow-derived cells to repair radiation-injured bladders. We used a three-dimensional bioprinting robot system to

Changes in bladder wall blood oxygen saturation in the overactive obstructed bladder.

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OBJECTIVE Several studies suggest that hypoxia of the bladder wall contributes to bladder dysfunction but the exact relation between bladder function and blood oxygen saturation, a surrogate marker for hypoxia, is not known. We determined bladder wall blood oxygen saturation in vivo in an animal

Enhanced angiogenesis and relaxation of bladder as early response to bladder outlet obstruction.

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OBJECTIVE To provide insights into the pathogenesis of bladder insult secondary to bladder outlet obstruction. METHODS Six-week-old female Sprague-Dawley rats (n = 80) were divided into eight groups, 10 rats each, according to the duration of bladder outlet obstruction, including 0, 3, 6, 12, 24,

Effect of anoxia on in vitro bladder function.

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Previous studies have demonstrated that the ability of the in vitro whole bladder to empty in response to bethanechol administration was inhibited by anoxia while its ability to generate pressure decreased only slightly. One question was not addressed by these early studies: Is the anoxic effect

The role of biomarkers in bladder preservation management of muscle-invasive bladder cancer.

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OBJECTIVE Patients with localized muscle-invasive bladder cancer (MIBC) can choose to undergo either neoadjuvant chemotherapy followed by radical cystectomy or radiation therapy-based bladder preservation treatment modality with subsequent close cystoscopic surveillance with salvage cystectomy

Bladder attack: transient bladder ischemia leads to a reversible decrease in detrusor compliance.

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The deleterious effects of chronic ischemia on bladder function have been extensively studied; however, evaluation and characterization of the effects of acute ischemia and hypoxia are lacking. The present study examined pig and human detrusor smooth muscle (DSM) strips, in combination

Mesenchymal stem cell recruitment and improved bladder function after bladder outlet obstruction: preliminary data.

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OBJECTIVE Mesenchymal stem cells have various therapeutic benefits in various organ injury models. Bladder outlet obstruction causes smooth muscle hypertrophy and fibrosis, leading to lowered compliance, increased storage pressures and renal injury. Decreased blood flow and hypoxia may contribute to

Overactive bladder syndrome and bladder wall thickness in patients with obstructive sleep apnea syndrome.

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OBJECTIVE The main objective of the present study was to evaluate the presence of overactive bladder (OAB) syndrome, nocturia, urgency, and urge incontinence in patients with obstructive sleep apnea syndrome (OSAS), and measure bladder wall thickness (BWT) in these patients. METHODS The patient

Gall bladder distention in newborns.

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Three cases of gall bladder distention in asphyxiated newborns are described. Clinical and ultrasound examination showed this to be a benign, transient phenomenon. A causal relation between tissue hypoxia and gall bladder distention is proposed.
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