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bladder/protease

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Страна 1 од 248 резултати

Protease-activated receptor-2-mediated contraction in the rat urinary bladder: the role of urinary bladder mucosa.

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The role of protease-activated receptor-2 (PAR-2) in the regulation of the rat urinary bladder contractility was investigated. Both trypsin and PAR-2 activating peptide (SLIGRL-NH(2)) produced a concentration-dependent contractile response in the urinary bladder preparations. These contractions were

Defense mechanisms of urinary bladder: studies on antimicrobial polypeptides from bladder mucosa.

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The acid-soluble extract of the bladder mucosal surface was obtained by washing out the bladder with dilute acetic acid in the presence of protease inhibitors. The wash-out materials from rats, rabbits, pigs, and humans manifested strong bactericidal activity against E. coli in vitro. The

Chemoprevention of bladder cancer.

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There is a growing body of basic science and epidemiologic evidence to support a research thrust to determine whether several natural or synthetic agents, given alone or together, can lower cancer incidence. Candidate agents include analogs of vitamin A and the vitamin A precursor, beta-carotene,

Up-regulation of protease activated receptors in bladder after cyclophosphamide induced cystitis and colocalization with capsaicin receptor (VR1) in bladder nerve fibers.

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OBJECTIVE Studies suggest that protease activated receptors (PARs) are mediators of inflammation and repair. Studies suggest a neurogenic mechanism for PAR2 in inflammation and the fact that interaction between PAR2 and transient receptor vanilloid receptor (TRPV1 or VR1) are important for the

Disulfide high mobility group box-1 causes bladder pain through bladder Toll-like receptor 4.

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BACKGROUND Bladder pain is a prominent symptom in several urological conditions (e.g. infection, painful bladder syndrome/interstitial cystitis, cancer). Understanding the mechanism of bladder pain is important, particularly when the pain is not accompanied by bladder pathology. Stimulation of

Excretory bladder: the source of cysteine proteases in Paragonimus westermani metacercariae.

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The cysteine proteases of Paragonimus westermani metacercariae are involved in metacercarial excystment, host immune modulation, and possibly in tissue penetration. In order to clarify the origin of the enzymes, 28 and 27 kDa cysteine proteases in metacercarial excretory-secretory products were

Endogenous H2S sensitizes PAR4-induced bladder pain.

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Bladder pain is a prominent symptom of interstitial cystitis/painful bladder syndrome. Hydrogen sulfide (H2S) generated by cystathionine β-synthase (CBS) or cystathionine γ-lyase (CSE) facilitates bladder hypersensitivity. We assessed involvement of the H2S pathway in protease-activated receptor 4

The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.

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Cathepsin D was measured in cytosols of 60 malignant bladder specimens and normal tissue from the same bladder at safety margin 5 cm of the tumor. Significant elevation in cathepsin D level (50 +/- 3.5 pmol/mg protein) in bladder carcinoma compared to normal tissue (12.7 +/- 1.58 pmol/mg protein)

Graft pancreatitis and hemorrhagic cystitis. Treatment with bladder irrigation and protease inhibition.

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Early cysteine protease activity in excretory bladder triggers metacercaria excystment of Paragonimus westermani.

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The cysteine proteases of Paragonimus westermani metacercaria are known to initiate metacercaria excystment. However, their secretory sites, such as the intestine, tegument, and excretory bladder are not well defined. In this study, the metacercariae were labeled with bromodeoxyuridine (BrdU) to

Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1.

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Pain is the significant presenting symptom in Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Activation of urothelial protease activated receptor 4 (PAR4) causes pain through release of urothelial macrophage migration inhibitory factor (MIF). High Mobility Group Box-1 (HMGB1), a

Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation.

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BACKGROUND All four PARs are present in the urinary bladder, and their expression is altered during inflammation. In order to search for therapeutic targets other than the receptors themselves, we set forth to determine TFs downstream of PAR activation in the C57BL/6 urinary bladders. METHODS For

Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.

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BACKGROUND Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR). Urothelial PAR1 receptors were shown to mediate bladder inflammation. We showed that PAR1 and PAR4 activator,

Effects of various food ingredients on gall bladder emptying.

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OBJECTIVE The emptying of the gall bladder in response to feeding is pivotal for the digestion of fat, but the role of various food ingredients in contracting the gall bladder postprandially is not well understood. We hypothesized that different food ingredients, when consumed, will have a different

Protease-activated receptor stimulation activates a Ca2+-independent phospholipase A2 in bladder microvascular endothelial cells.

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Increased mast cell numbers and mast cell activation represent one of the prevalent etiologic theories for interstitial cystitis, an inflammatory condition in the bladder. This study was designed primarily to determine whether increased mast cell tryptase in the bladder wall may play a role in
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