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cystathionine/рак

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12 резултати

Use of hydrogen sulfide synthesis inhibitors for cancer therapy

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BACKGROUND Colorectal cancer is a common form of cancer, the incidence of which is increasing worldwide. Various methods, including fecal occult blood test and colonoscopy, are currently used for screening colorectal cancer and have increased the rates of detection for early-stage cancer. Colorectal

Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof

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SEQUENCE LISTING The instant application contains a sequence listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jan. 20, 2018, is named 218107_0003_03_US_ST25.txt and is 45,280 bytes in size. BACKGROUND OF

Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof

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BACKGROUND OF THE INVENTION The sequence listing that is contained in the file named "GGEOP0004USD2_ST25.txt", which is 45 KB (as measured in Microsoft Windows.RTM.) and was created on Feb. 10, 2016, is filed herewith by electronic submission and is incorporated by reference herein. 1. Field of the

Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof

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The sequence listing that is contained in the file named "GGEOP0004USD1_ST25.txt", which is 45 KB (as measured in Microsoft Windows.RTM.) and was created on Mar. 21, 2014, is filed herewith by electronic submission and is incorporated by reference herein. BACKGROUND OF THE INVENTION 1. Field of the

Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof

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BACKGROUND OF THE INVENTION 1. Field of the Invention The invention generally relates to compositions and methods for the treatment of cancer with enzymes that deplete L-Methionine. More particularly, it concerns the engineering of a novel human methionine-.gamma.-lyase enzyme with methionine

Engineered primate L-methioninase for therapeutic purposes

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the fields of medicine and biology. More particularly, it concerns an improved human methionine-.gamma.-lyase (hMGL) for use in the treatment of cancer. 2. Description of Related Art The demand for the

Engineered primate L-methioninase for therapeutic purposes

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the fields of medicine and biology. More particularly, it concerns an improved human methionine-.gamma.-lyase (hMGL) for use in the treatment of cancer. 2. Description of Related Art The demand for the

Engineered primate L-methioninase for therapeutic purposes

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the fields of medicine and biology. More particularly, it concerns an improved human methionine-.gamma.-lyase (hMGL) for use in the treatment of cancer. 2. Description of Related Art The demand for the

Engineered primate L-methioninase for therapeutic purposes

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the fields of medicine and biology. More particularly, it concerns an improved human methionine-.gamma.-lyase (hMGL) for use in the treatment of cancer. 2. Description of Related Art The demand for the

Engineered primate cystine/cysteine degrading enzymes as antineogenic agents

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the fields of medicine and biology. More particularly, it concerns compositions and methods for the treatment of cancer with enzymes that deplete both L-cystine and L-cysteine. Even more particularly, it

Engineered primate cystine/cysteine degrading enzymes as antineogenic agents

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the fields of medicine and biology. More particularly, it concerns compositions and methods for the treatment of cancer with enzymes that deplete both L-cystine and L-cysteine. Even more particularly, it

Apigenin analogs, compositions, and methods related thereto

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BACKGROUND Certain embodiments are directed to the fields of chemistry and medicine. Certain aspects are directed to compounds for treating chronic pancreatitis, colon cancer, or liver fibrosis. Chronic pancreatitis (CP) is a progressive, non-curable disorder of the pancreas (Schneider and Whitcomb,
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