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The dark side of Sjögren's syndrome: the possible pathogenic role of infections.

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To highlight recent findings on pathogenic mechanisms and clinical associations which characterize the role of infectious agents as triggers for Sjögren's syndrome development.Several candidate infectious agents have been identified to induce the autoimmune

Immunoactive Photosensitizers Had Photodynamic Immunostimulatory and Immunomodulatory Effects on Mammalian Macrophages

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Photodynamic compounds have great potential in biological applications. Their controlled and localized activation with specific wavelength of light provides opportunities to evade the side effects of the therapy. Biologically compatible photosensitizers can be used in therapy against cancer,

Immunostimulatory properties of coffee mannans.

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Coffee infusion mannans are acetylated polysaccharides containing single Galp and Araf residues as side chains of a beta-(1 --> 4)-Manp backbone. These mannans are structurally similar to the bioactive acetylated mannans from Aloe vera (AV). In this study, acetylated mannans were obtained from two

Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells.

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Recent studies have demonstrated abundant transcription of a set of noncoding RNAs (ncRNAs) preferentially within tumors as opposed to normal tissue. Using an approach from statistical physics, we quantify global transcriptome-wide motif use for the first time, to our knowledge, in human and murine

Immune system stimulation by the gut symbiont Frischella perrara in the honey bee (Apis mellifera).

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Gut bacteria engage in various symbiotic interactions with their host and impact gut immunity and homeostasis in different ways. In honey bees, the gut microbiota is composed of a relatively simple, but highly specialized bacterial community. One of its members, the gammaproteobacterium Frischella

Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination.

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Immune system responses are under the control of extracellular biomolecules, which express functions in receptors present on the surface of cells of the immune system, and thus are amenable to be functionally modulated by monoclonal antibodies. Some of these mechanisms are activating and dictate

Continuous darkness and continuous light induce structural changes in the rat thymus.

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It is known that neuroendocrine responses to environmental stimuli, such as light, can influence immune responses through the pineal gland. It is also known that periods of constant darkness and constant light cause stimulation and inhibition of melatonin secretion from the pineal gland,

Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.

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Interleukin 10 (IL-10) is a pleiotropic cytokine with well known antiinflammatory, immunosuppressive, and immunostimulatory properties. Chronic allograft rejection, characterized by vascular neointimal proliferation, is a major cause of organ transplant loss, particularly in heart and kidney

Immunomodulatory properties of a pineal indole hormone other than melatonin, the 5-methoxytryptophol.

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Several experiments have suggested that the pineal gland has an antitumor immunomodulatory action. Melatonin (MLT), the best known pineal hormone, has been shown to stimulate anticancer immune defenses during the night, corresponding to the period of its maximum blood levels, whereas it has no

Use of quantitative flow cytometry to measure ex vivo immunostimulant activity of echinacea: the case for polysaccharides.

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BACKGROUND When directly exposed to various echinacea fractions, human leukocytes ex vivo are strongly stimulated to proliferate and to produce immunostimulation and inflammatory cytokines. A comparison of fractions containing lipoidal small molecules and high-molecular-weight water-soluble

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Herbal & Natural Medicine

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