4 резултати
FIELD OF THE INVENTION
The present invention relates to the use of a deoxynojirimycin derivative, or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of various diseases in which the synthesis of glucosylceramide and/or other glycosphingolipids play a
FIELD OF THE INVENTION
The present invention relates to deoxynojirimycyin analogues, or pharmaceutically acceptable salts thereof, that can suitably be used for the treatment of various diseases in which the synthesis of glucosylceramide and/or other glucosphingolipids play a role. Such diseases
INTRODUCTION
Glucosylceramide is the condensation product of UDP-glucose and ceramide and its formation is catalysed by glucosylceramide synthase (GCS, EC 2.4.1.80).
The enzymes involved in ceramide biosynthesis are localized on the cytosolic leaflet of the endoplasmic reticulum. The biosynthesis
INTRODUCTION
Glucosylceramide is the condensation product of UDP-glucose and ceramide and its formation is catalysed by glucosylceramide synthase (GCS, EC 2.4.1.80).
The enzymes involved in ceramide biosynthesis are localized on the cytosolic leaflet of the endoplasmic reticulum. The biosynthesis