the patients in this group take 6 xue-fu-zhu-yu capsules once, twice a day, for 7weeks.

the patients in this group take 6 xue-fu-zhu-yu capsule simulated agents once, twice a day, for 7weeks..

Qi Stagnation and Blood Stasis Syndrome

participants are given to 6 xue-fu-zhu-yu capsule per time, twice a day. The duration is 7 weeks

xue-fu-zhu-yu capsule

participants are given to 6 xue-fu-zhu-yu capsule simulated agent per time, twice a day. The duration is 7 weeks

xue-fu-zhu-yu capsule simulated agent

Guang'anmen Hospital, China Academy of Chinese Medical Sciences

Huguosi TCM Hospital Affiliated to Beijing University of CM

Wangjing Hospital, China Academy of Chinese Medical Sciences

The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome.

The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treating qi Stagnation and Blood Stasis Syndrome: a Multicenter, Double-blind, Randomized and Placebo-controlled Trial

The Traditional Chinese Medicine PRO scale includes physiological domain,psychological domain,independence and social domain. And the change of the total score of the Traditional Chinese Medicine PRO Scale in Patients of QS&BSS will be assessed.

Patients' single symptom and sign evaluation will use the score of the single symptom and sign scale of QS&BSS. According to the degree of symptom and sign, the score is given as no = 0; mild = 1; moderate = 2; severe = 3

The pain will be assessed by the score of the pain scale of QS&BSS. The total score includes visual analogue scale pain index and the score of degree, duration, and frequency of pain . The position of pain will be counted independently.

physical examination (temperature, respiration, heart rate, blood pressure, height and weight), complete blood cell count, urinalysis, stool examination, fecal occult blood test, liver function (ALT, AST, alkaline phosphatase (ALP), serum total bilirubin (STB), and γ-glutamyl transpeptidase (γ-GT)), renal function (Cr, BUN, and urine N-acetyl-β-glucosaminidase) and electrocardiogram (ECG)

Hao-qiang He

master degree candidate

Guang'anmen Hospital of China Academy of Chinese Medical Sciences

China Food and Drug Administration

Chinese Academy of Medical Sciences

Each patient will undergo mastectomy(ies) if immediate reconstruction is being performed, followed by uni- or bilateral abdominally based free flap harvest, microsurgical anastomoses, and flap inset. If randomized to the ketorolac intervention group, then the participant will receive 30 mg of intravenous (IV) ketorolac tromethamine. The anaesthetist will give participants their first study drug intravenously at the conclusion of surgery. The participant will then continue to receive their assigned drug every 6 hours for 72 hours, for a total of 13 doses. Patients all receive 1:1 care from nursing staff in the early postoperative period, and their nurse will administer all drugs given on the surgical ward.

Each patient will undergo mastectomy(ies) if immediate reconstruction is being performed, followed by uni- or bilateral abdominally based free flap harvest, microsurgical anastomoses, and flap inset. If randomized to the control group the patient will be given a sham IV medication. The sham medication will be normal saline at the same volume as ketorolac, which corresponds to 3 ccs. The anaesthetist will give participants their first study drug intravenously at the conclusion of surgery. The participant will then continue to receive their assigned drug every 6 hours for 72 hours, for a total of 13 doses. Patients all receive 1:1 care from nursing staff in the early postoperative period, and their nurse will administer all drugs given on the surgical ward.

Breast Cancer Female

Ketorolac Tromethamine

Normal Saline

Ketorolac for Analgesia followiNG Autologous Breast RecOnstructiOn

recorded in days beginning post operative day number one

Total narcotic consumption over first 72 hours converted to morphine equivalence

Total surgical drain output over first 72 hours

Any hematoma requiring management in the operating room

Any infection requiring antibiotics, or flap complications requiring management in the operating room

Joey Corkum

Physician

Nova Scotia Health Authority

5 mg prednisolone per os daily administration

The placebo is designed to the equal look like the study medication.

HIV Disease Progression

Prednisolone

Bugando Medical Center

Progression of HIV-Disease Under Low Dose Corticosteroids

A Phase II Clinical Trial to Assess Risk and Benefit of Oral Low Dose Prednisolone for HIV Infected People Prior to the Commencement of Antiretroviral Treatment

The primary objective of the study is to assess the effect of the low dose prednisolone therapy on the time to progression of HIV disease. The time to progression is defined as the time between the baseline and the change of staging to advanced disease (CDC stage A3, B3 or C) or death

The total CD4 cell count, measured in number of cells per µl, should be significantly higher in the intervention group.

The rate of survival should not differ significantly between the two groups.

The quality of life of participants, as measured by a standardised set of questions, should not differ significantly between the two groups.

The rate of co-infections should not be significantly higher in the intervention group.

In vitro studies on isolated lymphocytes of patients in both arms should show significant differences in their activation status.

gastritis/phosphatase

The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome.

Ketorolac for Analgesia followiNG Autologous Breast RecOnstructiOn

Progression of HIV-Disease Under Low Dose Corticosteroids

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