gingival overgrowth/phosphatase

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The role of phosphatase and tensin homolog in drug-induced gingival overgrowth.

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OBJECTIVE We proposed that phosphatase and tensin homolog (PTEN) might be one of the signaling proteins that alter the balance between cell growth and cell death in drug-induced gingival overgrowth. The aim of this study was to investigate the expression of PTEN in subjects using cyclosporine A and

DNA content and alkaline phosphatase expression in cells of different gingival overgrowths.

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The present study compared the alkaline phosphatase (ALPase) expression and DNA content at specific periods in cultured cells derived from non-inflamed enlarged gingivae of idiopathic gingivofibromatosis (IGF) and phenytoin-induced hyperplasia (PHG). Cultured cells from healthy gingiva or

[Acid phosphatase of the human gingiva in health and in chronic catarrhal and hypertrophic gingivitis, and in alveolar pyorrhea].

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Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report

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Introduction: Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) may manifest as one of four distinctive disorders: 1) Cowden syndrome; 2) Bannayan-Riley-Ruvalcaba syndrome; 3) Proteus syndrome; or 4) Proteus-like

Gingival hyperplasia in dogs induced by oxodipine, a calcium channel blocking agent.

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Subchronic oral exposure of dogs to Oxodipine, a new calcium channel blocker of the dihydropyridine-type, resulted in dose-related gingival hyperplastic changes. The doses at which an effect was elicited were 24 and 73 times the intended therapeutic dose for man. The effects were first noted after 7

Crevicular fluid levels of TGFbeta1 in drug-induced gingival overgrowth.

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OBJECTIVE To determine if local, gingival crevicular fluid (GCF) levels of TGFbeta1 were altered in drug-induced gingival overgrowth. METHODS GCF samples were collected on Periopaper strips from 45 renal transplant recipients who had been medicated with cyclosporin or cyclosporin in combination with

Alkaline phosphatase activity in cultured cells of human healthy and hyperplastic gingivae: a preliminary study.

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The present study compared the alkaline phosphatase (ALP) expression in cultured cells derived from different types of gingival hyperplasia. Tissue biopsies were obtained from patients with clinically non-inflamed, enlarged gingivae of idiopathic gingivofibromatosis (IGF) and phenytoin-induced

Phenytoin-mediated androgen metabolism in gingival fibroblasts. Effects of the antiandrogen finasteride and the alkaline phosphatase inhibitor levamisole.

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OBJECTIVE This investigation attempts to identify the role of the alkaline phosphatase inhibitor levamisole (L) and the antiandrogen finasteride (F) on 5alpha-reductase activity in gingival fibroblasts, to elucidate mechanisms for phenytoin-induced gingival overgrowth. METHODS Human gingival

Effects of diphenylhydantoin in 41 epileptics institutionalized since childhood.

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Institutionalized epileptic patients on long-term anticonvulsant diphenylhydantoin (DPH) therapy were examined clinically. DPH plasma levels were unexpectedly high in 54% despite rather poor seizure control. No patient was free from side effects, which included gingival hypertrophy (90% of

Long-term anticonvulsant therapy in tuberculous meningitis--a four-year follow-up.

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A treatment protocol for long-term anticonvulsant therapy (ACT) in children with tuberculous meningitis (TBM) has been followed depending upon clinical characteristics and EEG/CT scan findings suggestive of the underlying cause of convulsions. Sixty-three children which included all patients with

[Neonatal mucolipidosis type II].

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Mucolipidosis type II (ML II, OMIM 252,500) is an autosomal recessive disorder clinically characterized by facial dysmorphia similar to Hurler syndrome and pronounced gingival hypertrophy. The disorder is caused by a defect in targeting acid hydrolases on the surface of lysosomes, which impede their

Previous exposure to Cyclosporine A and periodontal breakdown in rats.

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OBJECTIVE The aim of this study was to evaluate the influence of previous exposure to Cyclosporine A (CsA) on experimental periodontitis in rats. METHODS Forty rats were divided into 4 groups: Control (CON); Cyclosporine A (CsA), which received daily doses of 10mg/kg CsA; Ligature (LIG), which

Tumor-induced rickets in a child with a central giant cell granuloma: a case report.

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Tumor-induced osteomalacia/rickets is a rare paraneoplastic disorder associated with a tumor-producing fibroblast growth factor 23 (FGF23). We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma (CGCG) with high serum levels of FGF23, a hormone

Effects of long-term cyclosporin therapy on the periodontium of rats.

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BACKGROUND The treatment of cyclosporin A triggers an early bone loss and gingival overgrowth. There is a lack of studies exploring the effects of long-term cyclosporin A therapy on alveolar bone homeostasis and gingival tissue. OBJECTIVE The purpose of this study was to evaluate the effects of

Vitamins for epilepsy.

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BACKGROUND Vitamins have been reported to be effective in controlling certain types of seizures and to prevent some of the harmful effects of antiepileptic drugs (AEDs). In this review we will summarize evidence from randomized controlled trials. OBJECTIVE To assess if vitamins improve seizure

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