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Clinical microbiologists have developed a two-step algorithm in which an EIA or a RDT is first used to screen stools for the presence of glutamate dehydrogenase (GDH) antigen derived from C. difficile. The GDH antigen test is very specific (> 95%) and negatives could be reported right away, only
On Day 1, subjects with diarrhea defined as having three or more unformed bowel movements or >200 mL of unformed stool (for subjects having rectal collection devices) within 24 hours, confirmed by a rapid CDI test (positive for both toxins A & B and glutamate dehydrogenase) to have CDI will be
Clostridium difficile (CD) is a gram positive, spore forming anaerobic bacillus that is not a normal commensal of the gastrointestinal tract. It was initially named "difficult clostridium" because it was difficult to isolate and grow on culture media. CD can exist in spore and vegetative forms.