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Lethal ricin intoxication in two adult dogs: toxicologic and histopathologic findings.

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Two adult dogs with the same owner were intoxicated by ingestion of fertilizer composed of residual plant material of the castor bean plant (Ricinus communis L.). Both dogs died within 2 and 3 days, respectively, after the first signs of vomiting and abundant hemorrhagic diarrhea. Toxicologic and

Toxicity of Jatropha curcas phorbol esters in mice.

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Phorbol esters are the main toxins in Jatropha curcas seed and oil. The aim of this study was to assess the acute toxicity of phorbol esters given by intragastric administration and to determine the LD50 for Swiss Hauschka mice. The LD50 and 95% confidence limits for male mice were 27.34 mg/kg body

Molecular cloning and characterization of phospholipase D from Jatropha curcas.

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Phospholipase D (PLD, EC 3.1.4.4) is a key enzyme involved in phospholipid catabolism, initiating a lipolytic cascade in membrane deterioration during senescence and stress, which was cloned from Jatropha curcas L., an important plant species as its seed is the raw material for biodiesels. The cDNA

Histopathological and Reproductive Evaluation in Male Rats Fed Jatropha curcas Seed Cake with or without Alkaline Hydrolysis and Subjected to Heat Treatment.

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Jatropha curcas cake, a by-product of biodiesel production, is rich in protein and has potential to be used in livestock feed; however, the presence of antinutritional factors and phorbol esters limits its use. Thus, this study investigated toxicological and reproductive effects in male Wistar rats

Structural characterization of copia-type retrotransposons leads to insights into the marker development in a biofuel crop, Jatropha curcas L.

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BACKGROUND Recently, Jatropha curcas L. has attracted worldwide attention for its potential as a source of biodiesel. However, most DNA markers have demonstrated high levels of genetic similarity among and within jatropha populations around the globe. Despite promising features of copia-type

Lethal Injection of a Castor Bean Extract: Ricinine Quantification as a Marker for Ricin Exposure Using a Validated LC-MS/MS Method.

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Ricin is a highly toxic agent derived from the castor bean plant (Ricinus communis). Poisoning occurs commonly by oral ingestion of the beans. Injection of ricin is believed to be more lethal. Ricin is a large glycosylated protein difficult to detect in clinical samples. Instead, ricinine, a small

Pathological study on mucosal changes in small intestine of rat by oral administration of ricin. I. Microscopical observation.

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A histological study on small intestine of Wistar rats after oral administration of ricin, a proteinous toxin from castor bean seeds, was carried out. In Experiment I, the jejunum was examined at 1, 2, 5, 10, 15, 20, 24, and 40 hours after oral administration of ricin 30 mg/kg. In Experiment II,

Pathological effects of feeding roasted castor bean meal (Ricinus communis) to chicks.

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Castor bean cake was prepared from castor bean seeds roasted at 140 degrees C for 20 min and found free from ricin by chemical analysis. The cake was incorporated into diets at 0, 10, 15, 20 and 25% levels and fed to ducks for 6 weeks. Diarrhoea, emaciation and death were observed mainly at 20 and

Expression of Phospholipase D during Castor Bean Leaf Senescence.

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Membrane deterioration in plant senescence is commonly associated with progressive decreases in membrane phospholipid content. This study investigated the expression and regulation of phospholipase D (PLD; EC 3.1.4.4) during senescence in castor bean (Ricinus communis L. cv Hale) leaf discs. The

Toxicity studies of detoxified Jatropha meal (Jatropha curcas) in rats.

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Jatropha curcas, a tropical plant introduced in many Asian and African countries is presently used as a source of biodiesel. The cake after oil extraction is rich in protein and is a potential source of livestock feed. In view of the high toxic nature of whole as well as dehulled seed meal due to

Characterization of stroma from Fuchs' endothelial dystrophy corneas.

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Fuchs' endothelial dystrophy is commonly regarded as an endothelial cell disorder. In the present study we compared glycoconjugates of Fuchs' and normal corneas using FITC conjugated lectins [peanut agglutinin (PNA), castor bean agglutinin (RCA120), soybean agglutinin (SBA), and wheat germ

Experimental sensory ganglionectomy by way of suicide axoplasmic transport.

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In attempts to destroy selectively the sensory ganglion cells via retrograde axoplasmic transport, either one or the other of the Ricinus communis agglutinins (RCA 60 and RCA 120), highly toxic lectins from castor beans, was topically applied to the proximal stump of the rat trigeminal branches (the

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