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A method for the production of D-tagatose using a recombinant Pichia pastoris strain secreting β-D-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp. 22c.

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BACKGROUND D-Tagatose is a natural monosaccharide which can be used as a low-calorie sugar substitute in food, beverages and pharmaceutical products. It is also currently being tested as an anti-diabetic and obesity control drug. D-Tagatose is a rare sugar, but it can be manufactured by the chemical

Mechanism of insulin-resistant glucose transport activity in the enlarged adipose cell of the aged, obese rat.

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The effects of increasing cell size on glucose transport activity and metabolism and on the concentrations of glucose transport systems in both the plasma and low density microsomal membranes in isolated adipose cells from the aging rat model of obesity have been examined. Glucose transport activity

Bifidobacterium as an oral delivery carrier of oxyntomodulin for obesity therapy: inhibitory effects on food intake and body weight in overweight mice.

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BACKGROUND Oxyntomodulin (OXM) is a gut hormone released from intestinal L cell. Synthetic OXM and its analog reduce food intake and body weight in both rodents and human beings by being administered intravenously. However, people find intravenous administration difficult because of its side effects

L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J Mice on High-Fat-Diet.

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Obesity and metabolic syndrome (MS) associated with excess calorie intake has become a great public health concern worldwide. L-arabinose, a naturally occurring plant pentose, has a promising future as a novel food ingredient with benefits in MS; yet the mechanisms remain to be further elucidated.

Protective effects of L-arabinose in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats.

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BACKGROUND L-Arabinose is a non-caloric sugar, which could affect glucose and lipid metabolism and suppress obesity. However, few reports have described the effect of L-arabinose in metabolic syndrome, a combination of medical disorders that increase the risk of diabetes and cardiovascular

Weight-loss drugs and supplements: are there safer alternatives?

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Obesity is a major cause of health complaints in western developed countries. Problems ranging from apnea to joint pain have been associated with excess weight. Many factors have been attributed to the epidemic of obesity including sedentary lifestyle, high-fat diets and consumption of large amounts

Glucose transport in isolated rat adipose cells.

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Several different approaches to the measurement of hexose transport rates in isolated adipocytes from lean and obese rats have been utilized in the last six years. The uptake as a function of time of the non-metabolizable sugar 3-0-methylglucose is so fast that until recently no measurements of the

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