The patients in treatment arm A group will be received moisturizer containing the active ingredients of licochalcone A, decanediol, L-carnitine, and salicylic acid on the right side of their face and placebo which is moisturizer without those active ingredients on the left side of their face.

The patients in treatment arm B group will be received moisturizer containing the active ingredients of licochalcone A, decanediol, L-carnitine, and salicylic acid on the left side of their face and placebo which is moisturizer without those active ingredients on the right side of their face.

Acne Vulgaris

Acne

Moisturizer with active ingredients: 1 fingertip unit to cover one side of the face twice a day

Moisturizer with active ingredients

Placebo: 1 fingertip unit to cover one side of the face twice a day

Placebo

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University

Moisturizer Containing Licochalcone A, Decanediol, L-carnitine and Salicylic Acid in Reducing Relapsing of Acne

A Randomized Controlled Trial of Efficiency of Moisturizer Containing Licochalcone A, Decanediol, L-carnitine and Salicylic Acid in Reducing Relapsing of Acne in Thai Acne Subjects

Acne lesion count was evaluated by counting papules, pustules and total number of inflammatory lesions between two sides of face.

Relapse rate is defined as a percentage of patient who had acne lesion count worse more than 50%.

Time to relapse is defined as time to which patient had acne lesion count worse more than 50%.

Side effects are defined as erythema, dryness, scaling, stinging, burning and pruritus.

Satisfaction is evaluated by overall VAS score.

Skin dyspigmentation is evaluated by Visia® and Antera® which determined melanin and hemoglobin parameters.

Stratum corneum hydration will be assessed by Corneometer®. The unit is Corneometer® units from 0-130.

Transepidermal water loss will be assessed by Tewameter® which reported in g/h/m2.

Skin sebum content will be assessed by Sebumeter®. The unit is Sebumeter® units from 0-350 (approximated to μg/cm2 in a certain range).

Mahidol University

Beiersdorf

Split face study. Half face is ramdomly applied moisturizer containing the active ingredients of licochalcone A, decanediol, L-carnitine, and salicylic acid. Another half face is assigned to use placebo which is moisturizer without those active ingredients.

Evening
Wash face by prepared facial foam and dry your face
Apply adapalene gel all over the face

Morning
Wash face by prepared facial foam and dry their face
Apply placebo cream all over the face
Evening
Wash face by prepared facial foam and dry your face
Apply adapalene gel all over the face
Apply placebo cream all over the face

Morning
Wash face by prepared facial foam and dry their face
Apply Eucerin cream all over the face
Evening
Wash face by prepared facial foam and dry your face
Apply adapalene gel all over the face
Apply Eucerin cream all over the face

Evening
Wash face by prepared facial foam and dry your face
Apply adapalene gel all over the face
Adapalene gel: Adapalene gel: 2 fingertip unit to cover all over the face before going to bed

Adapalene Gel

Morning
Wash face by prepared facial foam and dry their face
Apply placebo cream all over the face
Evening
Wash face by prepared facial foam and dry your face
Apply adapalene gel all over the face
Apply placebo cream all over the face
Adapalene gel with placebo moisturizer: Placebo: 2 fingertip unit to cover all over the face twice a day.
Adapalene gel: 2 fingertip unit to cover all over the face before going to bed

Adapalene Gel With Placebo Moisturizer

Morning
Wash face by prepared facial foam and dry their face
Apply Eucerin cream all over the face
Evening
Wash face by prepared facial foam and dry your face
Apply adapalene gel all over the face
Apply Eucerin cream all over the face
Adapalene gel with Eucerin: Eucerin: 2 fingertip unit to cover all over the face twice a day.
Adapalene gel: 2 fingertip unit to cover all over the face before going to bed

Adapalene Gel With Eucerin

Total

Gender

Region of Enrollment

Undesirable effects were evaluated from skin's condition/signs(erythema, dryness and scaling) are evaluated by dermatologist. (none; mild; moderate; severe) and subject interview/symptoms(stinging/burning and pruritis) are evaluated by participants.(none; mild; moderate; severe). There were assessed at 2nd week, 4th week, and 8th week.
The worst score of each parameter which was defined as the worst local tolerance score is demonstrated and compared among 3 groups as shown.

Reduction of Undesirable Effects

Evaluation from mean counts of inflammatory, noninflammatory, and total acne lesions at baseline, and at 2, 4, and 8 weeks
Total acne lesions = inflammatory + noninflammatory acne lesions
Reduction of lesions counts are considered to be a better outcome

Reduction of Severity of Acne

Skin tolerability was assessed by measuring the skin surface sebum content, skin hydration with the Sebumeter SM815 and Corneometer CM825, respectively

Skin Tolerability: Skin Sebum Content and Skin Hydration

Skin tolerability was assessed by measuring TEWL with the Tewameter TM300

Skin Tolerability: Transepidermal Water Loss (TEWL)

The ASI score was calculated from the number of papules + (2 x pustules) + (comedones/4)
Decrease of ASI score are considered to be a better outcome

Reduction of Severity of Acne: Acne Severity Index (ASI)

Overall Study

Papapit Tuchinda

Eucerin: 2 fingertip unit to cover all over the face twice a day. Adapalene gel: 2 fingertip unit to cover all over the face before going to bed

Adapalene gel with Eucerin

Adapalene gel: 2 fingertip unit to cover all over the face before going to bed

Adapalene gel

Placebo: 2 fingertip unit to cover all over the face twice a day. Adapalene gel: 2 fingertip unit to cover all over the face before going to bed

Adapalene gel with placebo moisturizer

Siriraj Hospital Mahidol Univeristy

An Efficiency of a Moisturizer Containing Licochalcone A, L-carnitine and 1,2-decanediol With Adapalene Gel in Acne

An Evaluator-blind, Randomized, Vehicle-controlled Efficiency of Adjunctive Usage of a Moisturizer Containing Licochalcone A, L-carnitine and 1,2-decanediol With Adapalene Gel for Improvement of Local Tolerance in Thai Acne Subjects

licochalcone a/erythema

Moisturizer Containing Licochalcone A, Decanediol, L-carnitine and Salicylic Acid in Reducing Relapsing of Acne

An Efficiency of a Moisturizer Containing Licochalcone A, L-carnitine and 1,2-decanediol With Adapalene Gel in Acne

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