10 резултати
BACKGROUND OF THE INVENTION
This invention generally relates to methods for maintaining, improving or increasing the synthesis of mucins, especially in the gastrointestinal tract and lungs. The invention further relates to maintaining, improving or increasing the synthesis of mucins in a patient by
FIELD OF THE INVENTION
This invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as asthma, chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic
FIELD OF THE INVENTION
This invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as asthma, chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic
FIELD OF THE INVENTION
This invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as asthma, chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic
SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Apr. 5, 2018, is named P224214US_WO_ST25_3429641.txt and is 858 bytes in size.
FIELD OF
TECHNICAL FIELD
The present invention relates to compositions and methods of treating inflammatory diseases, including inflammatory bowel disease, airway inflammation, cancer, and other inflammatory disorders, and methods for carrying out the methods.
BACKGROUND OF INVENTION
Inflammatory Bowel
SEQUENCE LISTING
This application incorporates by reference in its entirety the Sequence Listing entitled "Mucin_ST25.txt" (28.0 KB), which was created on Apr. 27, 2011 and filed electronically herewith.
FIELD
The present disclosure relates to therapeutic mucin proteins. In particular, the present
BACKGROUND OF THE INVENTION
The T cell/transmembrane, immunoglobulin, and mucin (TIM) gene family was positionally cloned in 2001 using a congenic mouse model of asthma. Since that time, a great deal of evidence has accumulated indicating that this gene family plays a critical role in regulating
BACKGROUND OF THE INVENTION
The astonishing complexity of the immune system is its greatest strength. The 10.sup.12-10.sup.14 possible antibody specificities, the delicate interplay between the various regulatory and effector cells, the restriction of T cell responses according to MHC antigens; all
BACKGROUND OF THE INVENTION
The T cell/transmembrane, immunoglobulin, and mucin (TIM) gene family was positionally cloned in 2001 using a congenic mouse model of asthma. Since that time, a great deal of evidence has accumulated indicating that this gene family plays a critical role in regulating