Subjects with the diagnosis of idiopathic REM sleep behavior disorder

Healthy controls without the diagnosis of idiopathic REM sleep behavior disorder

Thyroid Function Tests(TFT), Vitamin B12, Folate, Complete Blood Count(CBC), Fasting Glucose, Liver Function Tests(LFT), Renal Function Tests(RFT), C-reactive protein(CRP), Fasting lipid, Iron profile, Phosphate, Calcium, Neurosteroid, Genetic analysis

REM Sleep Behavior Disorder

Neurodegeneration

Department of psychiatry, Faculty of Medicine, The Chinese University of Hong Kong

Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder

A 7-year Prospective Study of Idiopathic REM Sleep Behavior Disorder Cohort in Chinese Population: Determining the Optimal Characteristics of Biomarkers to Predict Neurodegenerative Diseases

The overall conversion rate of iRBD to neurodegenerative diseases. The diagnoses of neurodegenerative diseases will be ascertained by neurologists according to the standard diagnostic criteria.

The dynamic changes of the likelihood ratio of probability of prodromal Parkinson's disease in the patients with iRBD and healthy controls will be calculated based on the Movement Disorder Society (MDS) research criteria for prodromal Parkinson's disease.

Conversion rate of iRBD to neurodegenerative diseases in patients with high and low likelihood ratio of probability at baseline, the level of likelihood ratio was defined based on the Movement Disorder Society (MDS) research criteria for prodromal Parkinson's disease.

Researcher in other sleep centers are also conducting similar study, there may be a plan for further collaboration on sharing the database

Dr. Zhang Jihui

Principal Investigator

Chinese University of Hong Kong

Concurrent psychiatric illnesses according to the Mini International Neuropsychiatric Interview( M.I.N.I);
The onset of mental symptoms preceded the onset of RBD:
Onset of RBD symptom was younger than 50 years old (as most patients with pRBD tended to be younger at mid-40s with an earlier age onset than typical iRBD).

Age- and sex- matched with pRBD proband;
Concurrent psychiatric illnesses according to the Mini International Neuropsychiatric Interview( M.I.N.I);
Free of narcolepsy and other neurological diseases;
Absence of any RBD features as based on REM sleep behavior disorder questionnaire (RBDQ-HK) and v-PSG;
Free of neurodegenerative diseases.

Age- and sex- matched with pRBD proband;
Without lifetime psychiatric disorder according to Mini International Neuropsychiatric Interview( M.I.N.I);
Free of narcolepsy and other neurological diseases;
Absence of any RBD features as based on RBDQ-HK and v-PSG;
Free of neurodegenerative diseases.

Blood sample will be taken for genetic study.

The Chinese University of Hong Kong

Shatin Hospital

Prodromal Markers of First-degree Relatives of Patients With Psychiatric Disorders Comorbid With RBD

Prodromal Markers of α-synucleinopathy Neurodegeneration in the First-degree Relatives of Patients With Psychiatric Disorders Comorbid With REM Sleep Behavior Disorder

The prevalence of possible RBD based on the self-reported/proxy-reported RBD symptoms in RBDQ-HK among FDRs,

The mean differences in the percentage of REM-related EMG activity among FDRs in different groups

In this stage, the investigators didn't decide which information of IPD will share with other researchers

parasomnias/допамин

Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder

Prodromal Markers of First-degree Relatives of Patients With Psychiatric Disorders Comorbid With RBD

Најкомплетнија база лековитог биља подржана науком