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piperidine/повраћање
Веза се чува у привремену меморију
Страна 1 од 22 резултати
Piperidine derivatives as substance P antagonists
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This application is a 371 of PCT/JP96/00796 filed Mar. 27, 1996.
TECHNICAL FIELD
The present invention relates to new piperidine derivatives having an antagonism on Substance P, being a peptide neurotransmitter, and pharmaceutically acceptable acid addition salts thereof. The piperidine derivatives
Benzoamide piperidine containing compounds and related compounds
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The present invention relates to certain benzoamide piperidine containing compounds and related compounds that exhibit activity as NK-1 receptor antagonists, (e.g., substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of
Piperidine derivative
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SUMMARY OF THE INVENTION
According to one aspect of our invention, we provide compounds of the general formula ##STR1## wherein R represents a halogen atom or a hydroxy, lower alkoxy, lower alkenyloxy, lower alkynyloxy or aralkyloxy (preferably a phenyl(lower)alkyloxy, e.g. benzyloxy) group, or a
Piperidine-piperazine ligands for neurotransmitter receptors
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
Piperidine-piperazine ligands for neurotransmitter receptors
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
Piperidine-piperazine ligands for neurotransmitter receptors
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
Pharmaceutical agents for treatment of emesis
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BACKGROUND OF THE INVENTION
The present invention relates to a method of treating or preventing emesis in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives, ethylene diamine derivatives and related compounds. The pharmaceutically
Piperidine derivatives
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FIELD OF THE INVENTION
This invention relates to piperidine derivatives, to processes for their preparation and to pharmaceutical compositions comprising them.
In particular the invention relates to compounds which are selective antagonists of 5-hydroxytryptamine (5-HT) at 5-HT.sub.3
Aroyl-piperidine derivatives and method of treating disorders induced by substance P
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DETAILED DESCRIPTION OF THE INVENTION
The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidin- es of the formula
##STR00002## wherein Y is .dbd.N-- or .dbd.N(O)--, R is OH when Y is .dbd.N-- and R is H when Y is .dbd.N(O)-- and the ring A is
Spiro-piperidine derivatives and their use as tachykinin antagonists
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This invention relates to a class of azacyclic compounds which are useful as tachykinin antagonists. More particularly, the compounds of the invention are spiro-substituted azacyclic derivatives.
The tachykinins are a group of naturally occurring peptides found widely distributed throughout
4-substituted piperidines, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
4,4-Disubstituted piperidines, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
4,4-Disubstituted piperidines, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
Piperidine derivatives and their use as therapeutic agents
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This invention relates to a class of heterocyclic compounds, which are useful as tachykinin receptor antagonists.
The tachykinins are a group of naturally occurring peptides found widely distributed throughout mammalian tissues, both within the central nervous system and in peripheral nervous and
Spiro-piperidine derivatives and their use as therapeutic agents
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This application claims priority from PCT/GB97/01630, filed Jun. 17, 1997, now WO97/49710 published Dec. 31, 1997 which claims priority under from Great Britain Application No. 9613108.1, filed Jun. 21, 1996, Great Britain Application No. 9625051.9 filed Dec. 2, 1996, Great Britain Application No.
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