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Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats.

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Puerarin, a major isoflavonoid derived from the Chinese medical herb Radix puerariae (kudzu root), has been reported to be useful in the treatment of various cardiovascular diseases. In the present study, we examined the detailed mechanisms underlying the inhibitory effects of puerarin on

Puerarin attenuates pressure overload-induced cardiac hypertrophy.

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BACKGROUND Puerarin is the most abundant isoflavonoid in kudzu root. It has been used to treat angina pectoris and myocardial infarction clinically. However, little is known about the effect of puerarin on cardiac hypertrophy. METHODS Aortic banding (AB) was performed to induce cardiac hypertrophy

Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury.

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Ischemic stroke (IS) is characterized by the sudden loss of blood circulation to an area of the brain, resulting in a corresponding loss of neurologic function. It has been a worldwide critical disease threatening to the health and life of human beings. Despite significant progresses achieved,

Puerarin provides a neuroprotection against transient cerebral ischemia by attenuating autophagy at the ischemic penumbra in neurons but not in astrocytes.

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Puerarin is an isoflavone derived from the Chinese medical herb of Radix puerariae (kudzu root), and has been widely used in the treatment for ischemic stroke in China. However, its underlying pharmacological mechanisms are still not understood. This study was to investigate the efficacy of puerarin

[Experimental study of protective effect of pueraria compound on the cerebral ischemic injury].

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OBJECTIVE To discuss the protective effects of pueraria compound on the cerebral ischemic injury. METHODS Using the middle cerebral artery occlusion model (MCAO) in rats and cerebral ischemia-reperfusion models in gerbils and mice, we investigated the influence of pueraria compound on the brain

[Protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury in rats].

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OBJECTIVE To research the protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury. METHODS Using the middle cerebral artery occlusion model (MCAO) in rats, we investigated the influence of pueraria flavonoid on the brain water content, the infarct volume, the activities

Anti-inflammatory effects of total isoflavones from Pueraria lobata on cerebral ischemia in rats.

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Puerariae radix, the dried root of Pueraria lobata Ohwi, is one of earliest and most important edible crude herbs used for various medical purposes in Oriental medicine. The aim of the present study was to determine the anti-inflammatory effects of Total Isoflavones from P. lobata (TIPL), which

Radix Puerariae: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.

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Radix Puerariae has been traditionally used for the treatment of diarrhea, acute dysentery, deafness and cardiovascular diseases. Yege (Gegen or Radix Puerariae lobatae), the dried root of Pueraria lobata (Wild.) Ohwi, has been widely used in China and, to a lesser extent, in Japan, Korea, and the

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