Vitamin C Deficiency

Smoking

Surgery

Surgery--Complications

Wound

Wound Complication

Wound Infection

Wound Dehiscence

Wound of Skin

Mandible Fracture

Mandible Open Fracture

Mandible Closed Fracture

Mandibular Fractures

Ascorbic Acid Deficiency

Oxidative Stress

Inflammation

Just after induction of anesthesia in the OR, subjects will be administered a single intravenous (IV) dose of Vitamin C at 66mg/kg/hr for 2 hours during surgery. Post-operatively (beginning the morning after surgery) Vitamin C Treatment Group subjects will receive a 4 week prescription of oral, liquid Vitamin C, 500mg by mouth two times a day. These dosages are known to be safe and effective.89-91

Vitamin C

Subjects will receive IV placebo (normal saline) identically packaged. Post-operatively Placebo Control Treatment Group participants will receive a 4-week prescription of the aqueous solution base used for the treatment group without the active component (Vitamin C).

Placebo

Hennepin Healthcare Research Institute

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients: A Double Blind, Placebo-controlled Randomized Clinical Trial

Biomarker of soft tissue repair. Measured in picogram/milliliter (pg/ml) in blood serum.

Biomarker of soft tissue repair. Measured in picogram/milliliter (pg/ml) in blood

Biomarker of soft tissue repair. Measured in nanogram/milliliter (ng/ml) in blood

Biomarker of soft tissue repair. Measured in micro Molar uM in blood

Biomarker of soft tissue repair. Measured in nanomol/microliter (nmol/ul) in blood

Biomarker of bone repair. Measured in enzyme unit/liter (U/L) in blood

Biomarker of bone repair. Measured in picogram/milliliter (pg/ml) in blood

Biomarker of bone repair. Measured in nanogram/milliliter (ng/ml) in blood

Vitamin C levels. Measured in nanomols (nmmol) in blood serum

Biomarker of tobacco exposure. Measured in nanograms/milliliter (mg/ml) in blood serum.

Wounds are scored from photographs using the InCISE wound score developed by the investigator.

scurvy/protease

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

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