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[Effects of heishunpian total alkaloids on Cassia acutifolia induced mice diarrhea and contraction of isolated intestinal smooth muscle in rats].

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OBJECTIVE To observe the effects of Heishunpian total alkaloids on Cassia acutifolia induced mice diarrhea and contraction of isolated intestinal smooth muscle in rats. METHODS The experiment was carried out with Cassia acutifolia induced mice diarrhea model, small intestinal propulsive rate in mice

Synergistic Effect of Berberine-Based Chinese Medicine Assembled Nanostructures on Diarrhea-Predominant Irritable Bowel Syndrome In Vivo

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is one common chronic functional disease of the digestive system with limited treatments. The microbiota-gut-brain axis (MGBA) has a central function in the pathogeny of IBS-D, which includes the participation of many various factors, such as

Intervention effect of Malus pumila leaf flavonoids on senna-induced acute diarrhea in BALB/c mice.

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The Malus pumila leaves are used as a kind of tea drink in China, and there are abundant flavonoids in the leaves of Malus pumila. In this study, BALB/c mice received senna extract solution via gavage, which induced acute diarrhea, and the interventive effect of Malus pumila

Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats.

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Senna and its main components sennosides are well-known effective laxative drugs and are used in the treatment of intestinal constipation in the world. Their potential side effects have attracted more attention in clinics but have little scientific justification. In this study, senna extract (SE),

Evaluation of Cassia obtusifolia (sicklepod) seed consumption in Holstein calves.

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Fifteen Holstein bull calves weighing 135-160 kg (300-350 lb) were randomly assigned to 3 groups of 5 animals each. Each calf was individually fed free choice Bermuda grass hay and 3.63 kg (8 lb) of a commercial 14% crude protein ration/day. Group 1 (control) received no Cassia obtusifolia seed,

Toxicological and hematological effects of sicklepod (Cassia obtusifolia) seeds in Sprague-Dawley rats: a subchronic feeding study.

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Cassia obtusifolia and its seeds, common contaminants of agricultural commodities, are toxic to cattle and poultry. Toxicity has been attributed to anthraquinones which are major constituents of C. obtusifolia, but studies of the subchronic and chronic toxicity of naturally occurring anthraquinones

Toxic myopathy and acute hepatic necrosis in cattle caused by ingestion of Senna obtusifolia (sicklepod; coffee senna) in Brazil.

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The epidemiological, clinical and pathological findings of field and experimental Senna obtusifolia (sicklepod; coffee senna) poisoning in cattle are described. The low availability of good quality forage and high rate of infestation of pastures by S. obtusifolia were the factors that led to

The toxicity of Cassia occidentalis to goats.

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The toxic effects of oral administration of Cassia occidentalis to goats was evaluated. The prominent signs of Cassia poisoning were diarrhea, inappetence, dyspnea, staggering, ataxia and recumbency. Lesions consisted of hemorrhages and congestion in the heart, lungs, abomasum and spleen, catarrhal

Preliminary isolation of a myodegenerative toxic principle from Cassia occidentalis.

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Aqueous and organic extractions of ground seeds of Cassia occidentalis were obtained. Chickens were dosed with extracted material to assess the toxicity of the extracts. Organic extracts with methanol, ethanol, chloroform, ethyl acetate, and benzene were ineffective in removing the toxin from the

Role of Anthraquinones in Cassia occidentalis induced Hepatomyoencephalopathy

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Ethnopharmacological relevance: The different plant parts of Cassia occidentalis Linn, (CO) such as root, leaves, seeds and pods have traditionally been used in multifarious medicines for the treatment of dysentery, diarrhea,

Randomized controlled trial of Cassia alata Linn. for constipation.

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Cassia alata Linn. is a medical plant. Its leaves have been claimed to be effective as a laxative. The studies done so far have shown no toxicity as a result of consuming Cassia alata Linn. leaves. The plant has been found to contain anthraquinones, presumed to be the active ingredient causing the

Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides.

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OBJECTIVE To report a case of chronic ingestion of very large amounts of senna fruits as an herbal tea, possibly leading to severe hepatotoxicity. METHODS A 52-year-old woman who had ingested, for >3 years, one liter of an herbal tea each day made from a bag containing 70 g of dry senna fruits,

Skin breakdown and blisters from senna-containing laxatives in young children.

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BACKGROUND At the direction of the Food and Drug Administration, phenolphthalein was removed from all over-the-counter laxatives in 1999. Phenolphthalein was then replaced in most laxative products with the natural product senna from Cassia acutifolia Delile, which contains various anthraquinones.

Anti-giardia activity and acute toxicity of a methanol extract of Senna racemosa bark.

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BACKGROUND Senna racemosa (Mill.) H.S. Irwin & Barneby (syn. Cassia racemosa Mill.) is a plant used in traditional Mayamedicinal practices to treat diarrhea. A methanol extract of S. racemosa bark has been shown to have in vitro activity against Giardia intestinalis. No studies of its efficacy and

Screening and identification of proteins mediating senna induced gastrointestinal motility enhancement in mouse colon.

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OBJECTIVE To isolate the proteins involved in pharmacologic action of senna extract (SE) from mouse gastrointestinal tract and to explore the molecular mechanism of gastrointestinal motility change induced by SE. METHODS SE was administrated to mice by different routes. Gastrointestinal motility of

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