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Fatal Taxus baccata ingestion with perimortem serum taxine B quantification.

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BACKGROUND Common yew (Taxus baccata) is a common decorative evergreen shrub with potentially fatal toxicity hallmarked by seizure, arrhythmia and cardiovascular collapse if ingested. Taxine B has been identified as one of the most cardiotoxic taxine alkaloids in Taxus spp, and another alkaloid,

Incubation of European yew (Taxus baccata) with white-tailed deer (Odocoileus virginianus) rumen fluid reduces taxine A concentrations.

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Yew ( Taxus baccata) foliage was co-incubated with rumen fluid (RF) taken from fistulated cattle (Bos taurus), anesthetized white-tailed deer (Odocoileus virginianus) and O. virginianus killed by bow hunters. The first trial with live deer resulted in statistically significant 59% reduction of

Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves.

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The yew tree (Taxus baccata) is an evergreen conifer that is widespread over central and southern Europe. The toxic effects of this conifer and its leaves have been known since ancient times. The seeds are generally responsible for accidental intoxications in childhood, whereas the bark and the

"Chaotic Arrhythmia" During Successful Resuscitation After Ingestion of Yew (Taxus baccata) Needles.

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OBJECTIVE The study aims to describe the management of a case of life-threatening yew (Taxus baccata) intoxication. BACKGROUND The needles of the yew tree contain highly cardiotoxic taxines. Intoxication with taxines, typically as part of suicide attempts, may lead to potentially lethal arrhythmias

[Electrophysiology of the mechanisms of action of the yew toxin, taxine, on the heart].

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The effects of the sulfate salt of taxine, the alkaloid mixture of the yew (Taxus baccata L.), on membrane currents of enzymatically isolated single ventricular cells of guinea pig were studied under current- or voltage clamp conditions. It was found that the drug inhibits both the sodium (INa) and

Laser Desorption/Ionisation Mass Spectrometry Imaging of European Yew (Taxus baccata) on Gold Nanoparticle-enhanced Target.

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BACKGROUND European yew (Taxus baccata) is a plant known to man for centuries as it produces many interesting and important metabolites. These chemical compounds were repeatedly analysed by various analytical techniques, but none of the methods used so far allowed the localisation of the chemical

Generic detection of basic taxoids in wood of European Yew (Taxus baccata) by liquid chromatography-ion trap mass spectrometry.

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The occurrence of the cardiotoxin taxine (comprising taxine B and several other basic taxoids) in leaves of Taxus baccata L. (European yew) is well known and has led to public concerns about the safety of eating or drinking from utensils crafted from the wood of this poisonous species. The

The medieval physician Avicenna used an herbal calcium channel blocker, Taxus baccata L.

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Calcium channel blockers are drugs which are important for current medical therapy. The first examples of synthetic congeners of this class of drugs appear around at the beginning of the 1960s. Review of the current and historical literature shows that Avicenna (Ibn Sina) (980-1037) had used the

[4 cases of poisoning with the extract of yew (Taxus baccata) needles].

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Four prisoners drank a decoction of yew (Taxus baccata) needles containing the toxic alkaloid taxine++ B. Two died in prison (one in the cell, the other shortly after admission to prison hospital, death was caused in both cases by cardiac arrest). Two other prisoners were admitted to the Warsaw

[Analysis of taxus baccata alkaloids in biological samples with the use of chromatographic methods].

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The aim of the experiment was to develop a method of the identification of taxines (taxine B and isotaxine B) from Taxus leaves and its application to the analysis of biological samples collected from the deceased girl. The object of the investigation was the analysis of taxines in post-mortem

Eight cases of fatal and non-fatal poisoning with Taxus baccata.

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This paper describes two fatalities, three non-fatal intentional and three accidental oral ingestions of yew (Taxus baccata) leaves. In all cases the post-mortem external examinations showed no signs of violence. Internal examinations revealed small green, needle-like particles on the tongue, in the

A suicide attempt by intoxication with Taxus baccata leaves and ultra-fast liquid chromatography-electrospray ionization-tandem mass spectrometry, analysis of patient serum and different plant samples: case report.

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Taxus (yew) is one of the most frequently reported plants causing potentially fatal outcome when taken incidentally or for suicidal reasons. A fast and reliable method of detection of poisonous compounds or their metabolites is critical in life-saving procedures in cases of yew ingestion.

Semisynthesis of Some 7-Deoxypaclitaxel Analogs from Taxine B.

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Taxine B (3), isolated from the dried needles of Taxus baccata, was converted into six novel 7-deoxypaclitaxel analogs, 20, 21a,b, and 23-25, that have structural changes at C1, C2, and C4. A method for the introduction of the benzoyl function at C2, via a benzylidene acetal at C1-C2, will be

Comparative determination of the cardioselectivity of taxine and verapamil in the isolated aorta, atrium and jejunum preparations of rabbits.

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The calcium channel antagonistic effect of taxine (CAS 12607-93-1) (active principle of leaves of English yew; Taxus baccata L.) was investigated in isolated aorta of rabbit, and its organ selectivity was determined and compared with that of verapamil (CAS 52-53-9) in isolated aorta, atrium and

Negative chronotropic and atrioventricular blocking effects of taxine on isolated frog heart and its acute toxicity in mice.

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The alkaloid mixture of yew ( TAXUS BACCATA) was converted to sulphate salt and this salt form of the drug was used throughout the experiments. The median lethal doses (LD50) and their 19/20 confidence limits of two samples of the drug, the freshly prepared and the stored taxine sulphate, were

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