Antiplatelet Resistance Research in Patients With Peripheral Arterial Revascularization
Nyckelord
Abstrakt
Beskrivning
In peripheral arterial disease, several studies have shown that the existence of an APR is predictive of the occurrence of thrombotic events but not all. The investigators can therefore ask the question of the benefit of adaptation of antiplatelet therapy by biological monitoring to prevent the recurrence of thrombotic events. The platelet aggregation tests used mainly concern aspirin, via stimulation with arachidonic acid, or anti-P2Y12 (clopidogrel, ticagrelor, prasugrel), via stimulation with adenosine diphosphate (ADP). For the latter, a test via the measurement of the phosphorylation of a cytoplasmic protein called "VASP" is also used routinely, making it possible to further clarify the existence of platelet resistance to anti-P2Y12. Within the vascular medicine department, any discovery of a potential resistance to the anti-platelet treatment of a patient requires a therapeutic adaptation to overcome this phenomenon of "resistance", and to improve the phenomenon of anti-aggregation
Datum
Senast verifierad: | 07/31/2018 |
Först skickat: | 05/14/2019 |
Beräknad anmälan inlämnad: | 05/14/2019 |
Först publicerad: | 05/15/2019 |
Senaste uppdatering skickad: | 05/16/2019 |
Senaste uppdatering publicerad: | 05/20/2019 |
Faktiskt startdatum för studien: | 12/31/2017 |
Uppskattat primärt slutdatum: | 02/28/2018 |
Beräknat slutfört datum: | 03/30/2018 |
Tillstånd eller sjukdom
Fas
Armgrupper
Ärm | Intervention / behandling |
---|---|
search for antiplatelet resistance Patients who were hospitalized in the vascular medicine department and who benefited from a search for antiplatelet resistance between April 2014 and November 2017. |
Urvalskriterier
Åldrar berättigade till studier | 18 Years Till 18 Years |
Kön som är berättigade till studier | All |
Testmetod | Non-Probability Sample |
Accepterar friska volontärer | Ja |
Kriterier | Inclusion Criteria: - Patients older than 18 years - All patients who were hospitalized in the vascular medicine department and who received a search for antiplatelet resistance between April 2014 and November 2017. Exclusion Criteria: - Opposition to participation in the study - Absence of follow-up after antiplatelet resistance testing |
Resultat
Primära resultatåtgärder
1. Number of re-occlusion of the revascularization procedure [1 year]
Sekundära resultatåtgärder
1. Number of cardiovascular events [1 year]