Association Between Helicobacter Pylori and Inflammatory Bowel Disease

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Assiut University

KLINISK PRÖVNING: NCT03820284

BioSeek: NCT03820284

Nyckelord

Abstrakt

Introduction:

Helicobacter pylori has been linked to a variety of gastric and extra gastric diseases. Chronic infection with H. pylori causes histologically evident gastritis in all colonized individuals and is the predominant risk factor for gastric and duodenal ulcers as well as gastric adenocarcinoma. However, increasingly robust experimental and epidemiological evidence suggests that H. pylori may at the same time be beneficial to its carriers, as it efficiently prevents allergic disorders and chronic inflammatory conditions .

Inflammatory bowel disease (IBD) is characterized by chronic, nonspecific intestinal inflammation with an unexplained pathology and an alternating relapsing and remitting clinical progression. IBD is divided into two subtypes: ulcerative colitis (UC) and Crohn's disease (CD). Most studies in the IBD field attribute its etiology to the complex interactions among immune dysfunction, genetic susceptibility of the host, and environmental risk factors.

Since the twenty-first century, improving hygienic conditions and socioeconomic status have reduced the H. pylori infection rate and this trend has concurrently been accompanied by an increased IBD incidence in most countries Numerous studies have reported a lower H. pylori infection rate in patients with CD and/or UC than in non-IBD control individuals. although a small number of studies showed no significant association .Recently, emerging epidemiologic studies and animal experiments revealed an inverse correlation between H. pylori infection and IBD onset, suggesting that H. pylori colonization exerts a special protective effect on autoimmune diseases

observation Cross sectional study will be conducted at assuit university hospitals on all patients with inflammatory disease to detect the prevalence of helicobacter pylori among them .Then the examined patients will be divided in to two group receiving the same medication group A : inflammatory bowel disease patient with H.PYLORI group B: inflammatory bowel disease Patient without H.PYLORI longitudinal study will be conducted to both group to study the clinical outcomes in both group .

Beskrivning

PATIENT AND METHOD :

1. Thorough medical history and full clinical examination will be taken from all patient including

-Personal history focus on special habit especially smoking

-documented previous history for H.pylori eradication

- Onset and duration of inflammatory bowel disease

- current medication

- presence of any extra intestinal manifestation of Inflammatory bowel disease

- presence of any complications from Inflammatory bowel disease

2. Investigation :

-All patients with inflammatory bowel disease will be tested for presence or absence of H.PYLORI by histological examination of endoscopically biopsied gastric mucosa

-his to logical examination of colonic mucosal every 3 months

-complete blood count

-serum albumin

-c reactive protein, erythrocyte sedimentation rate (ESR).

-fecal calprotectin if possible

- assess the severity of among both group (A,B) every 3 month for 2years. ulcerative by Mayo Score/Ulcerative Colitis Disease Activity Index and Crohn's disease by Montreal classifications for Crohn's Disease .

Mayo Score/Ulcerative Colitis Disease Activity Stool frequency 0 = Normal 1 = 1-2 stools/day more than normal 2 = 3-4 stools/day more than normal 3 = 4 stools/day more than normal Rectal bleeding 0 = None 1 = Visible blood with stool less than half the time 2 = Visible blood with stool half of the time or more 3 = Passing blood alone Mucosal appearance at endoscopy 0 = Normal or inactive disease 1 = Mild disease (erythema, decreased vascular pattern, mild friability) 2 = Moderate disease (marked erythema, absent vascular pattern, friability, erosions) 3 = Severe disease (spontaneous bleeding, ulceration) Physician rating of disease activity 0 = Normal 1 = Mild 2 = Moderate 3 = Severe

Datum

Senast verifierad:	12/31/2018
Först skickat:	01/18/2019
Beräknad anmälan inlämnad:	01/24/2019
Först publicerad:	01/28/2019
Senaste uppdatering skickad:	01/28/2019
Senaste uppdatering publicerad:	01/29/2019
Faktiskt startdatum för studien:	01/31/2019
Uppskattat primärt slutdatum:	01/31/2019
Beräknat slutfört datum:	01/31/2021

Tillstånd eller sjukdom

Helicobacter Infections

Fas

Armgrupper

Ärm	Intervention / behandling
Group A Group A inflammatory bowel disease with helicobacter pylori infection
Group B Inflammatory bowel disease without helicobacter pylori infection

Urvalskriterier

Kön som är berättigade till studier	All
Testmetod	Non-Probability Sample
Accepterar friska volontärer	Ja
Kriterier	Inclusion Criteria: - all inflammatory bowel disease at assiut university will be included and examined in cross sectional study for detection of presence of H.pylori in one year 2019-2020 .then the examined patients will be divided in two group A ,B according to presence or absence of H pylori . Both group will be studied in cohort study for two years Exclusion Criteria: - -patients with history of administration of proton pump inhibitor or antibiotics with in eight weeks . - patients with history of recent upper gastrointestinal bleeding

Resultat

Primära resultatåtgärder

1. prevalance of H.pylori among patients with inflammatory bowel disease [One years]

Number of patient with inflammatory bowel disease with H.pylori infection

2. Mayo score activity index among ulcerative colitis patients with H.pylori and without H.pylori [Two years]

Stool frequency 0 = Normal 1 = 1-2 stools/day more than normal 2 = 3-4 stools/day more than normal 3 = 4 stools/day more than normal Rectal bleeding 0 = None 1 = Visible blood with stool less than half the time 2 = Visible blood with stool half of the time or more 3 = Passing blood alone Mucosal appearance at endoscopy 0 = Normal or inactive disease 1 = Mild disease (erythema, decreased vascular pattern, mild friability) 2 = Moderate disease (marked erythema, absent vascular pattern, friability, erosions) 3 = Severe disease (spontaneous bleeding, ulceration) Physician rating of disease activity 0 = Normal 1 = Mild 2 = Moderate 3 = Severe

3. Mucosal healing among inflammatory bowel disease with H.pylori and without H.pylori [1years]

Histological examination of the biopsied colonic mucosal every 3 months in both groups

Association Between Helicobacter Pylori and Inflammatory Bowel Disease

Nyckelord

adenocarcinoma

blödning

inflammation

ulcer

erytem

hypersensitivitet

stomach diseases

colitis

magkatarr

albumin