Molecular Mechanisms of Raspberries Effect on Insulin Resistance and Inflammation
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StatusAvslutad
Sponsorer
Pennington Biomedical Research Center
Samarbetare
National Processed Raspberry Council
Louisiana State University and A&M College
KLINISK PRÖVNING: NCT04306406
BioSeek: nct04306406
Nyckelord
Abstrakt
Red raspberries (Rubus idaeus) are a good source of health enhancing hydrolyzable and condensed tannins, flavonoids, anthocyanins, phenolic acids, rheosmin, potassium, carotenoids, vitamin C, and vitamin K1. Compared to other berries commonly consumed in the US, the health benefits of red raspberries to improve pre-diabetes mellitus (PDM) and type 2 diabetes have never been explored. The clinical study proposed in this project seeks to investigate the protective effect of whole red raspberries against insulin resistance, oxidative stress, and inflammation in PDM and type 2 diabetic patients. The in vitro study proposed in the project will assist in identifying the molecular mechanisms by which whole red raspberry protect islet cells against oxidative stress, insulin resistance and loss of cell function.
Datum
| Senast verifierad: | 02/29/2020 |
| Först skickat: | 07/29/2019 |
| Beräknad anmälan inlämnad: | 03/09/2020 |
| Först publicerad: | 03/11/2020 |
| Senaste uppdatering skickad: | 03/09/2020 |
| Senaste uppdatering publicerad: | 03/11/2020 |
| Faktiskt startdatum för studien: | 01/06/2015 |
| Uppskattat primärt slutdatum: | 01/12/2017 |
| Beräknat slutfört datum: | 01/12/2017 |
Tillstånd eller sjukdom
Inflammation
Insulin Resistance
Intervention / behandling
Other: Raspberry Smoothies
Fas
-
Armgrupper
| Ärm | Intervention / behandling |
|---|---|
| Other: Raspberry Smoothies Single serving smoothies drink made with red raspberries to be consumed daily for two weeks | Other: Raspberry Smoothies Red raspberry smoothies drink |
Urvalskriterier
| Åldrar berättigade till studier | 18 Years Till 18 Years |
| Kön som är berättigade till studier | All |
| Accepterar friska volontärer | Ja |
| Kriterier | Inclusion Criteria: - type 2 diabetes Exclusion Criteria: - hypoglycemic agents - Pregnant or nursing a child - chronic medication that does not have a stable dose for greater than one month - anti-inflammatory medication - inflammatory disease |
Resultat
Primära resultatåtgärder
1. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) [2 weeks]
Ratio of fasting insulin and glucose
2. A high-sensitivity C-reactive protein (hs-CRP) measured in milligrams per liter [2 weeks]
Measure of systemic inflammation
Sekundära resultatåtgärder
1. 3,4-Dihydroxyphenylacetic acid (DOPAC) measured in nanograms per milliliter [2 weeks]
Measure of systemic inflammation
