Prevention of Narcotic-Induced Nausea
Nyckelord
Abstrakt
Beskrivning
Patients will be randomized to one of two study groups. They will then be asked to rate their pain and nausea on a line graph. If the patient is a female of child bearing age, a urine pregnancy test will be done per standard of care. After this, an IV catheter will be placed in a vein in the patients arm. Pain medicine will be given through this IV per the doctor's order. With this medicine, patients will be given 10 milliliters (2 teaspoons) of either Sodium Chloride (salt water) or Phenergan mixed with Sodium Chloride (salt water). Phenergan is a medication typically used to help with nausea and is a common ingredient in prescription cough medicine.
After this is finished, patients will be asked to rate their pain and nausea in 30 minutes, and again 1, 2, and 4 hours later. If the doctor decides the patient is able to be discharged from the emergency room before the 4 hours are up, they will be asked to rate your pain and nausea again before going home, and the study will be stopped at that time.
Datum
| Senast verifierad: | 02/28/2014 |
| Först skickat: | 10/04/2007 |
| Beräknad anmälan inlämnad: | 10/04/2007 |
| Först publicerad: | 10/09/2007 |
| Senaste uppdatering skickad: | 03/11/2014 |
| Senaste uppdatering publicerad: | 03/12/2014 |
| Datum för första inlämnade resultat: | 05/28/2012 |
| Datum för första inlämnade QC-resultat: | 03/11/2014 |
| Datum för först publicerade resultat: | 03/12/2014 |
| Faktiskt startdatum för studien: | 01/31/2007 |
| Uppskattat primärt slutdatum: | 08/31/2009 |
| Beräknat slutfört datum: | 10/31/2009 |
Tillstånd eller sjukdom
Intervention / behandling
Drug: 1
Drug: 2
Fas
Armgrupper
| Ärm | Intervention / behandling |
|---|---|
| Placebo Comparator: 1 Patients will then be randomized to receive placebo, consisting of 10ml of normal saline solution to be administered intravenously with the narcotic | Drug: 1 10 c of saline |
| Active Comparator: 2 Patients will be randomized to 6.25mg of promethazine, consisting of 0.25ml of promethazine diluted in 9.75ml of normal saline. | Drug: 2 Physician ordered dose |
Urvalskriterier
| Åldrar berättigade till studier | 18 Years Till 18 Years |
| Kön som är berättigade till studier | All |
| Accepterar friska volontärer | Ja |
| Kriterier | Inclusion Criteria: 1. Patient in Christian Care Emergency Department 2. Require intravenous narcotics for painful condition 3. ≥18 years of age 4. Able to visually rate amount of pain and nausea Exclusion Criteria: 1. Hypersensitivity to promethazine or opioids 2. Patient requesting anti-emetic at enrollment 3. Narcotic administration in last 6 hours 4. Pregnancy or currently breast-feeding 5. Known seizure disorder 6. Medical Instability |
Resultat
Primära resultatåtgärder
1. Number of Patients Who Became Nauseated After IV Opiate Administration. [4 hours post opiate administration]
