The present invention relates to a method for preventing or treating obesity, diabetes, dyslipidemia, fatty liver or insulin resistance syndrome, comprising: administering to a mammalian subject in need thereof a therapeutically effective amount of a composition comprising adipic acid. The present composition containing adipic acid as an active ingredient is very effective in preventing or treating obesity, diabetes, dyslipidemia, fatty liver (preferably, non-alcoholic fatty liver) or insulin resistance syndrome. The composition of the present invention useful as pharmaceuticals compositions or functional food compositions has therapeutic efficacies for obesity, dyslipidemia or fatty liver, and also induces significant decrease in fasting glucose level and blood insulin level to improve type 2 diabetes, insulin resistance and related metabolic diseases.

Park; Tae Sun

Industry-Academic Cooperation Foundation, Yonsei University

Uses of adipic acid

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A is a five to eight membered monocyclic or a nine to twelve membered bicyclic heterocyclic ring, as further defined herein; Y is S, CH.sub.2, or CH; Z is CH or N; R.sup.7 and R.sup.9 are hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 is (C.sub.1-C.sub.6)alkoxy, OH, CN, (C.sub.1-C.sub.6)alkyl, halogen, or CF.sub.3; r and s are 0, 1, or 2; and R.sup.1 and R.sup.3 are as further defined herein. These compounds are agonists, partial agonists and/or modulators of the NPY4 receptor and may be used for the treatment and prophylaxis of obesity, food intake, and other diseases and conditions modulated by the NPY4 receptor. ##STR00001##

adipic acid/fetma

Uses of adipic acid

Substituted adipic acid amides and uses thereof

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