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Sida 1 från 16 resultat
Design and Synthesis of an Aniline Derivative with Biological Activity on Heart Failure
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Background: Several compounds have been synthesized as a therapeutic alternative for heart failure; however, its preparation requires special conditions.
Objective: The aim of
[Changes in fatty acid composition and lipid peroxidation activity in microsomal membranes of the liver in experimental myocardial infarct].
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The experiments on rats have shown, that coronary artery ligation caused distinct alteration in fatty acids composition of microsomal lipids of the liver during restoration period. Within 7-21 days after artery ligation content of fatty acids saturated was increased, but concentration of arachidonic
Fabricating an electroactive injectable hydrogel based on pluronic-chitosan/aniline-pentamer containing angiogenic factor for functional repair of the hippocampus ischemia rat model
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The hippocampus, a critical cerebral region involved in learning and memory formation, is especially vulnerable to ischemic defect. Here, we developed an injectable electroactive hydrogel based on pluronic-chitosan/aniline-pentamer with proper conductivity around 10-4 S/cm to achieve the
[Functioning of the monooxygenase system of the liver in experimental myocardial infarct].
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The experiments on rats have shown that coronary artery ligation reduces the content of microsomal cytochromes P-450 and b5 and causes amidopyrine-N-demethylation and aniline-p-hydroxylation disturbances that persist throughout a 3-week period of myocardial infarction. The investigation of
Adrenocortical suppression and myocardial infarction in non-arteriosclerotic (virgin) and arteriosclerotic (breeder) rats.
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Non-arteriosclerotic, virgin and arteriosclerotic, breeder rats were treated with aniline to suppress adrenal steroidogenic capacity and responsiveness to the stress of acute myocardial infarction. After two weeks of aniline treatment, some of the non-arteriosclerotic and arteriosclerotic animals
[Chromotrop-aniline blue stain for improved demonstration of fresh heart muscle fiber damage].
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The Chromotrop-Anilinblue (CAB) trichrome staining method, developed for liver specimens, enables rapid detection of fresh damage to myocardial fibers by staining contraction-bands bright red. Dehiscence of the transverse striation, although yet unexplained in its pathogenetic significance, becomes
New antiarrhythmic agents. 3. Primary beta-amino anilides.
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The synthesis and pharmacologic evaluation of primary beta-amino anilides, as well as comparisons with tocainide, lidocaine, and its beta homologue, are described. Substituted anilines were acylated with 3-bromoacyl chlorides and converted to the title compounds by direct amination or via
[Analysis of the literature on acute aromatic amino or nitro-compounds poisoning].
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OBJECTIVE
To review the clinical features of acute toxicity of aromatic amino and nitro compounds.
METHODS
A total of 110 papers reporting 1240 cases of acute toxicity induced by aromatic amino and nitro compounds from 1979 to 2013 were collected from CNKI, VIP, and Wanfang database, and were
Clinical application of therapeutic erythrocytapheresis (TEA).
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Therapeutic erythrocytapheresis (TEA) has been used in different diseases such as polycythemia vera (PV), secondary erythrocytosis or hemochromatosis as a process of the less cumbersome but more expensive phlebotomy. TEA is preferred in emergency conditions such as thrombocytosis or in conditions
`Cadmium induced cardiac inflammation in chicken (Gallus gallus) via modulating cytochrome P450 systems and Nrf2 mediated antioxidant defense.
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Cadmium (Cd) has been implicated in the pathogenesis of inflammation, myocardial infarction, angiocardiopathy, even cancers. However, it is unknown that Cd-induced cardiac toxicity through Nrf2-mediate antioxidant defense and Cytochrome P450 (CYP450) system. To ascertain the chemoprevention of
[Experimental anatomo-pathologic study in the myocardium of animals with arterial hypertension caused via a nitric oxide synthesis blocker].
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BACKGROUND
Cardiac hypertrophy and reactive (including perivascular) and reparative fibrosis in L-NAME model are similar to that of hypertensive and cardiomyopathic patients.
OBJECTIVE
To qualitatively evaluate the reactive (including perivascular) and reparative fibrosis, on days 21 and 35,
Two histological methods for recognition and study of cortical microinfarcts in thick sections.
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Cortical microinfarcts are the most widespread form of brain infarction but frequently remain undetected by standard neuroimaging protocols. Moreover, microinfarcts are only partially detectable in hematoxylin-eosin-stained (H and E) 4-10 µm paraffin sections at routine neuropathological
Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy.
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Cell therapy is a promising strategy to regenerate cardiac tissue for myocardial infarction. Injectable hydrogels with conductivity and self-healing ability are highly desirable as cell delivery vehicles for cardiac regeneration. Here, we developed self-healable conductive injectable hydrogels based
The application of selected histochemical and immunohistochemical markers and procedures to the diagnosis of early myocardial damage.
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Histochemical (= HIS) methods (haematoxylin-eosin, luxol fast blue, chromotrope aniline blue) and various immunohistochemical (= IH) markers (myoglobin, desmin, fibrinogen, complement C5b-9) were applied in parallel to test the efficiency, specificity and sensitivity for the recognition of early
Synthesis and evaluation of an anti-MLC1 × anti-CD90 bispecific antibody for targeting and retaining bone-marrow-derived multipotent stromal cells in infarcted myocardium.
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A key issue regarding the use of stem cells in cardiovascular regenerative medicine is their retention in target tissues. Here, we have generated and assessed a bispecific antibody heterodimer designed to improve the retention of bone-marrow-derived multipotent stromal cells (BMMSC) in cardiac
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