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Sida 1 från 20 resultat
Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present application pertains to N-mustard compounds, methods for their preparation, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions in therapy and treatment, for example, of cancer.
2.
Aniline derivatives
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The invention relates to aniline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the
Breast cancer cell growth-inhibiting enzyme inhibitors, method for the production thereof, and use thereof
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BACKGROUND OF THE INVENTION
According to epidemiological data, breast cancer is the most frequent form of cancer in women [1]. Particularly aggressive breast cancers are characterized by invasive and metastatic behavior [2]. The treatment of such aggressive breast cancers is extremely problematic
Substituted anilines as CCR(4) antagonists
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BACKGROUND OF THE INVENTION
Chemokines are chemotactic cytokines that are released by a wide variety of cells to attract macrophages, T cells, eosinophils, basophils and neutrophils to sites of inflammation (reviewed in Schall, Cytokine, 3:165-183 (1991), Schall, et al., Curr. Opin. Immunol.
Substituted anilines as CCR(4) antagonists
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STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT
Not Applicable
REFERENCE TO A "SEQUENCE LISTING," A TABLE, OR A COMPUTER PROGRAM LISTING APPENDIX SUBMITTED ON A COMPACT DISK
Not Applicable
BACKGROUND OF THE INVENTION
Chemokines are chemotactic cytokines
Substituted anilines as CCR(4) antagonists
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STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT
NOT APPLICABLE
REFERENCE TO A "SEQUENCE LISTING," A TABLE, OR A COMPUTER PROGRAM LISTING APPENDIX SUBMITTED ON A COMPACT DISK
NOT APPLICABLE
BACKGROUND OF THE INVENTION
Chemokines are chemotactic cytokines
Substituted anilines as CCR(4) antagonists
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STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT
NOT APPLICABLE
REFERENCE TO A "SEQUENCE LISTING," A TABLE, OR A COMPUTER PROGRAM LISTING APPENDIX SUBMITTED ON A COMPACT DISK
NOT APPLICABLE
BACKGROUND OF THE INVENTION
Chemokines are chemotactic cytokines
Disubstituted aniline compounds
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FIELD OF THE INVENTION
The present invention relates to a novel class of disubstituted aniline compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby
Abietic acid derivatives as anti-tumor agents
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BACKGROUND
1. Field
The disclosure of the present patent application relates to anti-tumor agents derived from natural products, and particularly to abietic acid derivatives as anti-tumor agents shown to have anti-cancer activity against two prostate cancer cell lines.
2. Description of the Related
2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof
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This application claims priority from CN application No. CN 201410401604.7, filed on Aug. 15, 2014. The entire contents of the above-mentioned application are incorporated herein by reference.
FIELD OF INVENTION
The present invention relates to a 2-(2,4,5-substituted aniline)pyrimidine derivative, a
Aniline-derived ligands for the thyroid receptor
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FIELD OF THE INVENTION
This invention relates to novel compounds which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor .beta., and to methods of preparing such compounds and to methods for using such compounds such as in the regulation of
Aniline-derived ligands for the thyroid receptor
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FIELD OF THE INVENTION
This invention relates to novel compounds which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor .beta., and to methods of preparing such compounds and to methods for using such compounds such as in the regulation of
Substituted anilines for treatment of animal diseases
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BACKGROUND OF THE INVENTION
The human retinoid X receptors (hRXRs) consist of three identified isoforms (.alpha., .beta., .gamma.) that function as transcription promoters often in partnership with other members of a larger nuclear receptor (NR) family of transcription regulators including the
Aniline derivatives, their manufacture and use as pharmaceutical agents
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BACKGROUND OF THE INVENTION
The present invention relates to novel aniline derivatives, to a process for their manufacture, pharmaceutical compositions containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents.
Protein tyrosine kinases (PTKs)
4-pyridinone compounds and their use for cancer
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The present invention generally relates to processes for preparing pyridinone compounds.
Met, also referred to as hepatocyte growth factor receptor (HGFR), is expressed predominantly in epithelial cells but has also been identified in endothelial cells, myoblasts, hematopoietic cells, and motor
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