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Meta-analysis of Randomized Controlled Trials on Vitamins and Mineral Supplementation for CVD Prevention and Treatment

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Search strategy: A literature search of the Cochrane Library, Medline and PubMed will be conducted with the following search terms: "dietary supplements or supplement*" AND "cardiovascular disease or myocardial infarction or stroke or cardiovascular death or mortality or all-cause mortality or

Muscadine Grape Seed Supplementation and Vascular Function

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Study Participants Participants were adult male and non-pregnant female outpatients ages 18-65 with one or more of the following cardiovascular risk factors: hypertension (blood pressure ≥ 140/90 or current treatment for hypertension); dyslipidemia (total cholesterol > 220 mg/dL + LDL cholesterol >

Physicians' Health Study II

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OBJECTIVES: Primary - To determine whether vitamin E every other day reduces the risk of developing prostate cancer in older healthy male physicians. - To determine whether daily vitamin C and/or a multivitamin reduces the risk of total cancer in these participants. - To determine whether vitamin E

Pooling of Cohort Studies on Diet & Coronary Disease

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DESIGN NARRATIVE: Specific hypotheses tested included an adverse effect of saturated fat and carotenoids (alpha-carotene, lutein, and lycopene), flavonoids, folic acid, and vitamin B6. Plausible biological interactions between nutrients, such as fatty acids of the n-6 and n-3 series were also

Compliance in the Physicians' Health Study

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BACKGROUND: The Physicians' Health Study was a randomized, double-blind placebo-controlled primary prevention trial designed to test whether 325 mg aspirin every other day reduced risks of cardiovascular disease and whether 50 mg beta-carotene on alternate days decreased cancer incidence among

Physicians' Health Study: Study of Low Cardiovascular Disease Mortality

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BACKGROUND: The Physicians' Health Study was a randomized, double-blind, placebo-controlled primary prevention trial designed to test whether 325 mg aspirin every other day reduced the risk of cardiovascular disease and whether 50 mg beta-carotene on alternate days decreased cancer incidence among

Observational Aspirin Use and CVD in the Physicians' Health Study

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DESIGN NARRATIVE: The aspirin component of the trial was terminated on January 25, 1988, due to a demonstrated benefit of aspirin on myocardial infarction. At that time, however, the number of strokes and CV deaths experienced by trial participants was inadequate to definitively evaluate these

Intimal Thickening and Antioxidants in Hispanics and Anglos (Los Angeles Atherosclerosis Study)

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BACKGROUND: A finding from the Cholesterol Lowering Atherosclerosis Study (CLAS), a clinical trial, indicated that common carotid intima-media thickness responded more rapidly and more markedly to LDL-C lowering treatment than angiographic coronary stenosis or carotid roughness. New data from a

Epidemiology of Acute Phase Protein and CHD

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BACKGROUND: The use of stored serum from the MRFIT cohort contributed additional information on how various lipid fractions and other serum constituents interact to produce atherosclerotic disease. The cost of performing such studies on a new cohort would be many times greater. DESIGN NARRATIVE: The

Inflammation, Infection, and Future Cardiovascular Risk

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BACKGROUND: The PHS is a cohort which included 14,916 men initially free of cardiovascular disease and cancer who provided plasma samples at study entry in 1982. These men were randomly assigned in a factorial design to aspirin or beta-carotene therapy, and have been followed prospectively for the

Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)

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The Women's Antioxidant and Folic Acid Cardiovascular Study tested the effects of vitamin C (500 mg/day), vitamin E (600 IU every other day), and/or beta carotene (50 mg every other day) on the risk of major cardiovascular events (a combined outcome of myocardial infarction, stroke, coronary

HDL-Atherosclerosis Treatment Study (HATS)

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BACKGROUND: More than one-third of patients with coronary disease have "low" high density lipoprotein cholesterol (HDLc) levels (less than 35 mg/dl; United States 20th percentile) and "normal" low density lipoprotein cholesterol (LDLc) (less than 145; United States mean), a group for whom current

Arterial Disease Multifactorial Intervention Trial (ADMIT)

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BACKGROUND: Multiple mechanisms are involved in the deposition of LDL-C into the arterial wall, and the prevention of such deposition as well as the removal of the LDL-particles. Further, there remain questions regarding what causes an existing plaque that has been stable for a long period of time

Randomized Trial of Aspirin and Cataracts in U.S. Physicians

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Cataract is one of the most common causes of impaired vision as well as the third leading cause of blindness in the United States. Cataract surgery is one of the safest and most successful of all operations. The National Eye Institute has estimated that if the progression of cataract could be slowed

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