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11 resultat
Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells.
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Multidrug resistance is a prevailing phenomenon leading to chemotherapy treatment failure in cancer patients. In the current study two known cytotoxic pseudoguaianolide sesquiterpene lactones; neoambrosin (1) and damsin (2) that circumvent MDR were identified. The two cytotoxic compounds were
Multiple anticancer effects of damsin and coronopilin isolated from Ambrosia arborescens on cell cultures.
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Terpenoids in plants are important sources for drug discovery. In this study, we extracted damsin and coronopilin, two sesquiterpene lactones, from Ambrosia arborescens and examined their anticancer effects on cell cultures. Damsin and coronopilin inhibited cell proliferation, DNA biosynthesis and
Sesquiterpene lactones; Damsin and Neoambrosin suppress cytokine-mediated inflammation in complete Freund's adjuvant rat model via shutting Akt/ERK1/2/STAT3 signaling
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Ethnopharmacologial relevance: Although Damsissa (Ambrosia maritima) is traditionally used as anti-inflammatory and diuretic, the biological activity and mechanism of action of its major constituents is to be elucidated.
Damsin, the cytotoxic principle of Ambrosia ambrosioides (Cav.) Payne.
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The chemistry of Ambrosia maritima L. II. Hydrogenation, oxidation, and dehydrogenation of ambrosin and damsin.
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The chemistry of Ambrosia maritima L. I. The isolation and preliminary characterization of ambrosin and damsin.
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Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae).
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A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ENT-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A ( 1), I ( 2), and R ( 3), as well
The molluscicidal properties of natural products from Ambrosia maritima.
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The molluscicidal properties of Damsin "I", Ambrosin "II", and tribromodamsin "III" were investigated against the intermediate hosts of schistosomiasis Biomphalaria alexandrina and Bulinus truncatus. Although Damsin was to some extent more toxic against B. alexandrina than the other two compounds,
Sesquiterpene lactones from Ambrosia arborescens Mill. inhibit pro-inflammatory cytokine expression and modulate NF-κB signaling in human skin cells.
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BACKGROUND
Ambrosia arborescens has been used in Andean traditional medicine to reduce problems associated with various inflammatory diseases and conditions, although the underlying mechanism is unknown.
UNASSIGNED
The sesquiterpene lactones (SLs) coronopilin and damsin, which are major secondary
Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative.
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New regimens are constantly being pursued in cancer treatment, especially in the context of treatment-resistant cancer stem cells (CSCs) that are assumed to be involved in cancer recurrence. Here, we investigated the anti-cancer activity of sesquiterpene lactones (SLs) isolated from Ambrosia
Ethanolic extract of Artemisia campestris subsp. glutinosa (Besser) Batt. inhibits HIV-1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF-κB pathway
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Ethno-pharmacological relevance: The genus Artemisia spp. is well known for its anti-infectious properties and its high content in anti-infectious compounds, like the well-known sweet wormwood (Artemisia annua L.). Another Artemisia
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