Morbid obese subjects who will consent to bariatric surgery

Morbid obese subjects who will not consent to bariatric surgery but instead opt for dietitian led life style intervention

Mild- Moderate subjects assigned through a randomized controlled trial to the dietitian led life style intervention

Mild- Moderate subjects assigned through a randomized controlled trial to conventional care

Non-Alcoholic Fatty Liver Disease

Obesity, Morbid

Brown Fat

Metabolic Disease

Diabetes Mellitus

Insulin Resistance

Abdominal Subcutaneous Fat

Use of the normal bariatric surgery procedures commonly conducted in our hospital, such as: Laparoscopic Roux-en-Y gastric bypass (RYGB) and Laparoscopic sleeve gastrectomy (LSG)

Bariatric surgery

Intensive 6 months life style changes supervised by diatitians.

Dietitian led life style modification intervention

Conventional care (control)

The Chinese University of Hong Kong, Prince of Wale Hospital

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention

Abdominal subcutaneous fat in milliliters

Homeostatic model assessment (HOMA) (Fasting glucose in nanomoles per liter (nmol/L) and insulin in (micro-units Per Litre).

To measure Triglycerides in millimoles per litre (mmol/L)

To measure high density lipoproteins in millimoles per litre (mmol/L)

To measure Low-Density Lipoproteins in millimoles per litre (mmol/L)

To measure ALT in International Units Per Litre (IU/L)

To measure AST in International Units Per Litre (IU/L)

To measure gamma-glutamyltransferase (GGT) in International Units Per Litre (IU/L)

BMI in kg/m^2 (weight in kg and height in meters)

Systolic and Diastolic Blood pressure in millimeters of mercury (mmHg)

Professor Winnie W.C. Chu

Professor

Chinese University of Hong Kong

Four groups of interventional groups will be applied. Group 1 for subjects with morbid obesity who have consented to bariatric surgery, Group 2 for subjects with morbid obesity and have opted for dietitian led lifestyle modification intervention, Group 3 and 4 for subjects with mild to moderate obesity randomly (RCT) assigned to either dietitian led life style modification intervention group or conventional care (control group).

dl alanine/hepatitis

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

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