furocoumarin/hypersensitivitet

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Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation.

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Bergapten (5-methoxypsoralen, 5-MOP) is a plant-derived furocoumarin with demonstrated anti-inflammatory action. The present study investigated its effects on allergic inflammation in two related pathways of mast cell degranulation. Compound 48/80 and lipopolysaccharide (LPS) were used to activate

Iatrogenic phytophotodermatitis resulting from herbal treatment of an allergic contact dermatitis.

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Phytophotodermatitis commonly occurs in skin exposed to sunlight after contact with plants containing furocoumarins. While it is recognized that the consumption of plants or vegetables containing furocoumarins can potentially trigger a phytophotodermatitis, there have been no reports to date of a

Allelism of Saccharomyces cerevisiae genes PSO6, involved in survival after 3-CPs+UVA induced damage, and ERG3, encoding the enzyme sterol C-5 desaturase.

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Sequencing of the yeast gene that complemented the sensitivity to the photoactivated monofunctional 3-carbethoxypsoralen of the pso6-1 mutant strain revealed that the ERG3 locus, encoding sterol C-5 desaturase involved in biosynthesis of ergosterol, is allelic to PSO6. Disruption of the ERG3 gene

[Skin irritating substances in plants].

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A review is given on plants and plant constituents which can cause dermal hurts. There is distinguished between contact dermatitis, phytophoto dermatitis, and contact allergy. The active principles are biogenic amines, lactones, diterpenic esters, furocoumarins, quinones, longchain phenols, and

[Photo oxidative reactions of psoralens and their role in therapy of dermatoses].

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Psoralenes (furocoumarins) in combination with ultraviolet (UV) A radiation (320-400 nm) are used in the treatment of vitiligo, psoriasis, cutaneous T-cell lymphoma and other skin and autoimmune diseases (PUFA therapy). The mechanism of psoralene-photosensitive modification of biologically

Phytophotodermatitis.

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Several plant families contain species liable to cause phytophotodermatitis. They include the Umbelliferae of which Ammi majus has been known for centuries and the Rutacea to which Citrus bergamia belongs. Phototoxic plants are also found in, e.g., the Moraceae, Leguminosae, Rosaceae and Compositae

Five Cases of Phytophotodermatitis Caused by Fig Leaves and Relevant Literature Review.

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Phytophotodermatitis is a condition caused by sequential exposure to photosensitizing substances present in plants followed by ultraviolet light. Several plants (e.g., limes, celery, fig, and wild parsnip) contain furocoumarin compounds (psoralens). It is important for dermatologists to be aware of

Phytodermatitis in eastern Turkey: a retrospective, observational study.

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BACKGROUND Plant life is extremely diverse, with a great deal of geographic and seasonal variation. Consequently, the range of reported adverse reactions is large, and there are important differences worldwide in the incidence and prevalence of these reactions. Systemic ingestion of some plants

[Skin diseases associated with environmental factors].

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BACKGROUND Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease. OBJECTIVE Provide an overview of non-allergic skin diseases associated with environmental factors. METHODS Review of current scientific evidence for

Effects of Angelicin on Ovalbumin (OVA)-Induced Airway Inflammation in a Mouse Model of Asthma.

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Angelicin, a furocoumarin found in Psoralea corylifolia L. fruit, has been reported to have anti-inflammatory activity. The purpose of this study was to determine the protective effects of angelicin on allergic asthma induced by ovalbumin (OVA) in mice. Mice were sensitized to OVA (on days 0 and 14)

Adverse and beneficial effects of plant extracts on skin and skin disorders.

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Plants are of relevance to dermatology for both their adverse and beneficial effects on skin and skin disorders respectively. Virtually all cultures worldwide have relied historically, or continue to rely on medicinal plants for primary health care. Approximately one-third of all traditional

Photoallergic contact dermatitis to 8-methoxypsoralen in Ficus carica.

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BACKGROUND Photocontact dermatitis to Ficus carica is induced by furocoumarins present in sap. These substances are generally considered to cause phototoxic reactions. OBJECTIVE We conducted a patch test and histopathological study of patients with phytophoto contact dermatitis from the fig tree to

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