Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound of formula (I): ##STR00001## More particularly, it relates to said anti-prostate cancer compound that can be isolated from Garcinia esculenta or chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.

Hong Kong Baptist University

Pharmaceutical composition comprising guttiferone F for the treatment of prostate cancer

Three pairs of C-2 epimeric xanthones isolated from Garcinia hanburyi and method for efficiently separating the xanthone compounds into individual epimers, each of which possesses varying biological effects. The compounds are useful for their anticancer effects, particularly because they are shown to be non-substrates of the multidrug-resistance transporter. Some of the epimers have significant inhibitory effects on cytochrome P450 systems. The xanthone compounds of the present invention are gambogic acid, epigambogic acid, isogambogic acid, isoepigambogic acid, 30-hydroxygambogic acid and 30-hydroxyepigambogic acid.

Hong Kong Jockey Club Institute of Chinese Medicine Ltd.

Compounds from Garcinia hanburyi, their use in treating cancer and method of separating epimers thereof

The present invention provides compound extracted from Garcinia species and the use of said compound in preventing and treating cancer.

Shanghai University of Traditional Chinese Medicine

Medical use of compound from Garcinia esculenta

The present invention relates to a field of pharmaceutical chemistry, more specifically, the present invention relates to a garcinia derivative Formula (I), its preparing method, and medicinal use. Wherein the definitions of R.sub.1 and R.sub.2 are disclosed in the specification of the present invention, and the derivative of the present invention is a structurally simplified analogue of the gambogic acid compound; wherein the gambogic acid compound possesses anti-cancer characteristics, and could be used for preparation of anti-tumor drugs. ##STR00001##

garcinia lucida/neoplasms

Pharmaceutical composition comprising guttiferone F for the treatment of prostate cancer

Compounds from Garcinia hanburyi, their use in treating cancer and method of separating epimers thereof

Medical use of compound from Garcinia esculenta

Garcinia derivative, its preparing method and medicinal use

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