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[A case from practice (350). Mesangioproliferative glomerulonephritis (IgA nephritis)--nephrotic syndrome. Type II diabetes mellitus. Arterial hypertension (WHO-stage II)--grade II fundus hypertension. Chronic bronchitis following long-term nicotine abuse].

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Primary glomerulonephritis and hydrocarbon exposure: a case-control study and literature review.

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A case-control study was undertaken to investigate the possible role of chronic hydrocarbon exposure and tobacco and alcohol consumption in the causation of primary glomerulonephritis. Exposure to hydrocarbons and the consumption of tobacco and alcohol were assessed blindly by telephone interview

Mesangial proliferative glomerulonephritis with deposits of anti-nicotinic acetylcholine receptor antibody in a patient with myasthenia gravis.

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A patient with myasthenia gravis developed nephrotic syndrome 3 years after thymectomy. The kidney biopsy specimen revealed mesangial proliferative glomerulonephritis with immune deposits. The glomerular mesangial cells and tubular epithelial cells were sensitive to alpha-bungarotoxin (alpha-BT), a

Levamisole/Cocaine Induced Systemic Vasculitis and Immune Complex Glomerulonephritis.

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Levamisole is an antihelminthic and immunomodulator medication that was banned by the USFDA in 1998. It has been increasingly used to adulterate cocaine due to its psychotropic effects and morphological properties. Adverse reactions including cutaneous vasculitis, thrombocytopenia, and

Predictors of renal outcomes in anti-neutrophil cytoplasmic antibody glomerulonephritis.

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Glomerulonephritis associated with anti-neutrophil cytoplasmic antibody (ANCA) vasculitis still has a high prevalence of end-stage renal disease (ESRD), particularly in patients with advanced renal failure at presentation. This study aims to evaluate the clinical and histo- pathological features of

Nicotine worsens the severity of nephropathy in diabetic mice: implications for the progression of kidney disease in smokers.

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Epidemiological studies have established the role of cigarette smoking as a risk factor in the progression of chronic kidney disease, including diabetic nephropathy. We have previously reported that nicotine promotes mesangial cell proliferation and hypertrophy via activation of nonneuronal

Goodpasture's Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association.

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Introduction. Goodpasture's syndrome is a rare clinical entity and is characterized by circulating autoantibodies which are principally directed against the glomerular/alveolar basement membrane. The etiology of Goodpasture's syndrome is still unknown. Lung involvement occurs as a result of lung

Occupational hydrocarbon exposure and diabetic nephropathy.

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Exposure to hydrocarbons has been implicated in the pathogenesis of glomerulonephritis but its role in the development of diabetic nephropathy remains unknown. Three groups of patients with Type 1 diabetes of over 10 years duration were studied. Group 1 comprised 45 patients (23 F) with no diabetic

Smoking as a risk factor for end-stage renal failure in men with primary renal disease.

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BACKGROUND It is not known whether smoking increases the risk of end-stage renal failure (ESRF) in patients with primary renal disease. METHODS We performed a retrospective multicenter case-control study including 582 patients from nine centers in Germany, Italy and Austria. The diseases

Effects of smoking on renal hemodynamics in healthy volunteers and in patients with glomerular disease.

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Patients with renal disease who smoke have a poor renal functional prognosis, but the mechanisms involved have not been explored. In this controlled study, the effects of smoking and sham smoking were compared in 15 healthy normotensive volunteers. All were occasional smokers and abstained from

Hypocomplementemic urticarial vasculitis syndrome. Clinical and serologic findings in 18 patients.

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We identify and describe clinical findings in hypocomplementemic urticarial vasculitis syndrome (HUVS), an uncommon to rare illness related to systemic lupus erythematosus (SLE). A patient with recurrent, idiopathic urticaria-like lesions was diagnosed as having HUVS if a lesional biopsy showed

Cutting edge issues in Goodpasture's disease.

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Goodpasture's disease, or anti-glomerular basement membrane (anti-GBM) disease, is a systemic autoimmune disorder defined by anti-GBM antibody-mediated damage (mainly immunoglobulin G-1) resulting in progressive crescentic glomerulonephritis and, frequently, diffuse pulmonary alveolar hemorrhage. It

Alveolar hemorrhage in anti-basement membrane antibody disease: a series of 28 cases.

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Anti-basement membrane antibody disease is a rare disorder characterized by the presence of autoantibodies binding to the alveolar and glomerular basement membranes, and mediating both alveolar hemorrhage and acute glomerulonephritis. We retrospectively analyzed 28 cases of anti-basement membrane

Direct antiglobulin (Coombs) test in systemic lupus erythematosus patients.

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The objective of the study is to study the positivity of Coombs test or direct antiglobulin test (DAT) in systemic lupus erythematosus (SLE) patients and its relationship with disease's clinical and serological profile. Retrospective study of 373 SLE patients seen at single Rheumatology Unit.

Flavonoids in Kidney Health and Disease.

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This review summarizes the latest advances in knowledge on the effects of flavonoids on renal function in health and disease. Flavonoids have antihypertensive, antidiabetic, and antiinflammatory effects, among other therapeutic activities. Many of them also exert renoprotective actions that may be

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