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goiter/albumin

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Nitration of human serum albumin and bovine and human goiter thyroglobulins with tetranitromethane.

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Familial goitre with absence of thyroglobulin and synthesis of thyroid hormones from thyroidal albumin.

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Congenital goiter with hypothyroidism and iodo-serum albumin replacing thyroglobulin.

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Endemic goitre in Sarawak, Malaysia: I. Somatic growth and aetiology.

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A comparative epidemiological and anthropometric survey was conducted among Ibans, the largest indigenous ethnic group in Sarawak, in three regions where the endemicity of goitre exhibited marked differences , to assess the effect of endemic goitre on somatic growth. In the Ai river region the

Low-molecular-weight iodoproteins in the congenital goiters of cog/cog mice.

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Previously we described sedimentation and immunologic abnormalities of thyroglobulin (Tg) in a strain of mice with inherited congenital goiter and hypothyroidism (cog/cog). The goals of the present study were to determine the extent to which thyroid gland stimulation by TSH accounts for the abnormal

Defective thyroglobulin export as a cause of congenital goitre.

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The thyroids of two brothers aged 13 and 15 with congenital goitre, butanolinsoluble iodine in blood and which had pronounced decrease of immunoreactive thyroglobulin content in the thyroid were studied. Two types of thyroglobulin were identified. The first amounted to only about 200-300 mug/g wet

Familial and sporadic thyroglobulin deficiency with goitre and hypothyroidism.

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The thyroid proteins and iodocompounds were analysed in the thyroid tissue of 4 patients with nontoxic goitre. Subtotal thyroidectomy was performed for tracheal compression. The thyroid components were labelled with a trace amount of 125I before operation. One patient had congenital goitre and

Goiter and hypothyroidism in two siblings due to impaired Ca(+2)/NAD(P)H-dependent H(2)O(2)-generating activity.

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We report herein the study of two siblings (DESM and DSM) with hypothyroidism, goiter, and positive perchlorate discharge tests (50% and 70%) in a family (M) with no history of consanguinity. Thyroid gland histology showed a predominance of hyperactive follicles, with high epithelial cells and

[Effect of vitamin D deficiency on hypocalcaemia after total thyroidectomy due to benign goitre].

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BACKGROUND The purpose of this study was to analyse the relationship between preoperative serum levels of vitamin D and postoperative hypocalcaemia after total thyroidectomy. METHODS A prospective observational study was conducted on 113 patients treated by total thyroidectomy due to benign disease.

[Isoelectric spectra of blood serum albumin in patients with disturbed thyroid gland function and nephrotic syndrome].

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In patients suffering from diffuse toxic goiter, hypothyrosis and nephrotic syndrome changes in dynamics of treatment are found in the albumin molecule by means of the isoelectric focusing in the borate-polyol system and spectropolarimetry. The changes consist in an increased content of the albumin

Post-thyroidectomy hypocalcemia: the role of calcitonin, parathormone and serum albumin.

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To investigate the pathogenesis of post-thyroidectomy hypocalcemia calcium, phosphate, calcitonin, parathormone, albumin, triiodothyronine and thyroxine levels were monitored during operation and postoperatively in 25 female patients undergoing bilateral subtotal thyroidectomy for non-toxic nodular
Familial dysalbuminemic hyperthyroxinemia (FDH) has now become an established cause for spurious asymptomatic hyperthyroxinemia. Several different codon mutations on albumin gene had been identified. We here provided an established but rarely reported heterozygous mutation based on

Abnormal properties of thyroglobulin in mice with inherited congenital goiter (cog/cog).

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A recessive autosomal mutation (cog) in mice that results in congenital goiter was recently described. Since the mutation has been linked to the thyroglobulin (TG) gene, we have studied the immunological and physical properties of TG in cog/cog mice. +/Cog mice, which are phenotypically normal, were
Seven subjects belonging to three families (ME, MA, MO), with congenital goiter and various degrees of thyroid hypofunction, were investigated from the standpoints of clinical, biochemical, and molecular biology. In two of these families (ME, MA), 6 individuals had low serum levels of Tg-related

Clinical and morphologic findings of familial goiter in bongo antelope (Tragelaphus eurycerus).

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Inherited defects of thyroglobulin synthesis resulting in congenital goiter are well described in certain breeds of domestic ungulates and in human beings. Goiter associated with synthesis of an abnormal thyroglobulin and the presence of thyroidal albumin was identified in five closely related bongo
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