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goiter/carbohydrate
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[The carbohydrate metabolic characteristics of patients with diffuse toxic goiter proceeding with an increase in body weight].
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Altogether 10 patients (aged 15 to 18) with Basedow's disease, accompanied by a growing body mass were investigated before operation and 5 patients 6 mos. after subtotal strumectomy. Ten patients with Basedow's diseases without body mass increment were taken as controls. A characteristic feature of
[Changes in some indices of carbohydrate metabolism, cortisol metabolism, and the level of thyroid hormones under the effects of cocarboxylase in patients with toxic goiter].
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[EFFECT OF PREDOMINANTLY CARBOHYDRATE NUTRITION DURING IODINE DEFICIENCY IN COMBINATION WITH SOME FUNCTIONAL STRESSFUL SITUATIONS ON THE DEVELOPMENT OF EXPERIMENTAL GOITER].
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[Effect of neomycin on certain indicators of carbohydrate and cortisol metabolism and level of thyroid hormones in toxic goiter].
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[Some carbohydrate metabolism indices in toxic goiter].
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[Effect of preoperative preparation and surgical intervention on carbohydrate metabolism in middle aged and aged persons with goiter].
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[Some problems in regulating carbohydrate metabolism in diffuse toxic goiter patients].
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Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter.
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We analyzed the thyroglobulin (Tg) gene of 2 unrelated patients with congenital goiter and the Tg gene of 2 siblings with the variant type of adenomatous goiter. The clinical characteristics of the patients with congenital goiter and the variant type of adenomatous goiter were very similar, except
Defective thyroglobulin export as a cause of congenital goitre.
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The thyroids of two brothers aged 13 and 15 with congenital goitre, butanolinsoluble iodine in blood and which had pronounced decrease of immunoreactive thyroglobulin content in the thyroid were studied. Two types of thyroglobulin were identified. The first amounted to only about 200-300 mug/g wet
Elevated anti-galactosyl antibody titers in endemic goiter.
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Anti-Gal is a human polyclonal antibody that constitutes approximately 1% of the circulating immunoglobulin G (IgG), interacts specifically with the mammalian carbohydrate alpha-galactosyl epitope. Furthermore, it was found to mimic in vitro thyrotropin (TSH) effects regarding stimulation for cyclic
Hyposialylated thyroglobulin in a patient with congenital goiter and hypothyroidism.
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A large family (14 children) with congenital goiter whose parents are first cousins was studied. Thyroid tissue was obtained, after 125I in vivo labeling, from one of the siblings (JBM). Gel filtration of thyroid proteins indicated that thyroglobulin (Tg) eluted as a single symmetrical peak in the
Low molecular weight thyroglobulin leading to a goiter in a 12-year-old girl.
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We characterized the abnormal thyroglobulin (TG) in the thyroid and serum of a 12-yr-old girl with a large sporadic multinodular goiter first noted at age 4 yr. She developed normally and had no clinical evidence of hypothyroidism. However, her serum T4 was less than 1.0 microgram/dl, T3 was 125
Distribution of sialic acid-dependent carbohydrate epitope in thyroid tumors: immunoreactivity of FB21 in paraffin-embedded tissue sections.
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The reactivity of monoclonal antibody FB21, which recognizes a sialic acid-dependent carbohydrate epitope, was tested with 94 non-neoplastic and neoplastic thyroid tissue specimens using immunohistochemical methods on formalin-fixed, paraffin-embedded tissue sections. These specimens included 11
A study of thyroglobulin and peroxidase activity in the thyroid tissue of patients with non-endemic non-toxic nodular goitre.
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1. A study was made of the activity of the enzyme thyroid peroxidase and of the concentration, carbohydrate composition and the degree of iodination of thyroglobulin in the thyroid glands of 60 patients with non-endemic non-toxic goitre in the nodular phase and in those of 25 control subjects. 2.
[Effects of enzymatic deglycosylation of human goiter thyroglobulin on its immunochemical properties].
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Thyroglobulin (Tg), isolated from soluble iodoproteins by ammonium sulphate fractionation, was enzymatically deglycosylated in vitro and analyzed by polyacrylamide gel electrophoresis, double immunodiffusion and non-commercial RIA. Carbohydrate and iodine content was chemically determined. By PAAGE
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