hyperaldosteronism/albumin

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Renal damage in primary aldosteronism: a systematic review and meta-analysis.

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In experimental animal models, exogenous aldosterone excess has been linked to the progression of renal disease. However, the evidence of an increased risk of renal damage in patients affected by primary aldosteronism remains controversial. We aimed at evaluating the association

Albuminuria in untreated patients with primary aldosteronism or essential hypertension.

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OBJECTIVE The determinants and significance of urinary albumin excretion have been studied in normal subjects and in hypertensive patients; however, they are unknown in patients with primary aldosteronism. METHODS From a population of 114 patients with documented primary aldosteronism, we selected

Effectiveness of eplerenone or spironolactone treatment in preserving renal function in primary aldosteronism.

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OBJECTIVE Primary aldosteronism (PA) has deleterious effects on kidney function independent of blood pressure levels. Up to now, data on effectiveness of different PA therapies regarding renal function are scarce. METHODS This prospective multi-center study included 29 patients with newly diagnosed

[A case of nephrotic syndrome with diabetes mellitus and primary aldosteronism].

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A 65-year-old man had been followed by a family doctor for the treatment of hypertension and chronic hepatitis (type C) for about 20 years. Although he was pointed out to have impaired glucose tolerance and primary aldosteronism in 1995, he refused an adrenal tumor operation. He was admitted to our

Serum-soluble (pro)renin receptor concentration as a biomarker for organ damage in primary aldosteronism.

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Primary aldosteronism is characterized by inappropriate overproduction of aldosterone by adrenal lesions and leads to hypertension. Excess aldosterone causes organ damage; therefore, finding a biomarker for organ damage risk is vital. The (pro)renin receptor regulates the tissue

[Biomarkers of endothelial dysfunction and risk of early organ damage: a comparison between patients with primary aldosteronism and essential hypertension].

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OBJECTIVE To compare plasma concentrations of biomarkers of endothelial dysfunction between patients with primary aldosteronism (PA) and essential hypertension (EH), and to determine whether elevated levels of these biomarkers could predict development of early organ damage. METHODS Thirty-six PA

A primary aldosteronism-like phenotype identified with the aldosterone-to-angiotensin II ratio in black men: the SABPA study.

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Black populations may be more likely to have primary aldosteronism (PA) due to adrenal hyperplasia or other forms of adrenal hyperactivity, with suppressed renin levels and high levels of aldosterone, which may contribute to the development of

[The effect of albumin and furosemide administration in children with primary nephrotic syndrome (author's transl)].

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The authors have studied the effect of the infusion of sodium poor albumin on the primary nephrotic syndrome edema in children. The albumin dose used was 1 g per kilo, administered intravenously during four hours. A variable weight loss of 5.7% to 8.3% related to the initial weight was observed. The

Predictors of decreasing glomerular filtration rate and prevalence of chronic kidney disease after treatment of primary aldosteronism: renal outcome of 213 cases.

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BACKGROUND In primary aldosteronism (PA), glomerular hyperfiltration due to excessive aldosterone is considered to underestimate actual renal damage. OBJECTIVE Our objectives were to determine the prevalence of chronic kidney disease (CKD) in PA and identify the predictors of decreasing estimated

A direct enzyme immunoassay for 18-hydroxycortisol in urine: a new tool for screening primary aldosteronism.

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A microplate enzyme immunoassay has been developed for the measurement of 18-hydroxycortisol in urine. An antiserum was produced by immunization of rabbits with a 3-O-(carboxymethyl)oximino-18-hydroxycortisol-bovine serum albumin conjugate. IgG was isolated from the antiserum and was biotinylated.

Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism.

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The renal resistive index (RI) calculated by Doppler ultrasonography has been reported to be correlated with renal structural changes and outcomes in patients with essential hypertension or renal disease. However, little is known about this index in primary aldosteronism. In this prospective study,

[Comparison on metabolic disorders and uric acid levels between patients with primary aldosteronism and essential hypertension].

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Objective: To compare the incidence of metabolic disorders and uric acid (UA) levels between patients with primary aldosteronism (PA) and essential hypertension (EH), and to explore factors associated with UA levels in these patients. Methods: A total of 117 PA and 117 EH patients individually

Have main types of primary aldosteronism different phenotype?

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Primary aldosteronism (PA) is the most common cause of endocrine hypertension with a high frequency of cardiovascular complications. We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with

Transtubular potassium gradient predicts kidney function impairment after adrenalectomy in primary aldosteronism

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Background: In primary aldosteronism (PA), kidney function impairment could be concealed by relative hyperfiltration and emerge after adrenalectomy. We hypothesized transtubular gradient potassium gradient (TTKG), a kidney aldosterone

Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. 1962.

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A new syndrome, characterized by hypertrophy and hyperplasia of the juxtaglomerular apparatus of the kidneys, aldosteronism resulting from adrenal cortical hyperplasia, and persistently normal blood pressure is described in two patients. Overproduction of aldosterone could not be prevented by sodium

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